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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F12%3A11782%21RIV13-MZ0-00064165
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1159/000340031
dcterms:description
Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance. Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance.
dcterms:title
Vascular disturbances in primary aldosteronism: Clinical evidence Vascular disturbances in primary aldosteronism: Clinical evidence
skos:prefLabel
Vascular disturbances in primary aldosteronism: Clinical evidence Vascular disturbances in primary aldosteronism: Clinical evidence
skos:notation
RIV/00064165:_____/12:11782!RIV13-MZ0-00064165
n11:predkladatel
n19:ico%3A00064165
n3:aktivita
n10:Z n10:I
n3:aktivity
I, Z(MSM0021620807)
n3:cisloPeriodika
6
n3:dodaniDat
n15:2013
n3:domaciTvurceVysledku
n5:8115184 n5:1126431 n5:4834739 n5:9125035 n5:8498326 n5:1128469 n5:4934091
n3:druhVysledku
n14:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
177063
n3:idVysledku
RIV/00064165:_____/12:11782
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Primary aldosteronism; Blood vessels; Abnormalities
n3:klicoveSlovo
n12:Primary%20aldosteronism n12:Blood%20vessels n12:Abnormalities
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[BC51D3B70C0D]
n3:nazevZdroje
Kidney and Blood Pressure Research
n3:obor
n13:FA
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n15:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Holaj, Robert Zelinka, Tomáš Šomlóová, Zuzana Petrák, Ondřej Widimský, Jiří jr. Rosa, Ján Štrauch, Branislav
n3:wos
000314461100018
n3:zamer
n9:MSM0021620807
s:issn
1420-4096
s:numberOfPages
5