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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A9855%21RIV12-MZ0-00064165
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1161/CIRCULATIONAHA.110.015008
dcterms:description
Background-Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel of venous thromboembolism with fatal natural history; however, many cases can be cured by pulmonary endarterectomy. The clinical characteristics and current management of patients enrolled in an international CTEPH registry was investigated. Methods and Results-The international registry included 679 newly diagnosed (<= 6 months) consecutive patients with CTEPH, from February 2007 until January 2009. Diagnosis was confirmed by right heart catheterization, ventilation-perfusion lung scintigraphy, computerized tomography, and/or pulmonary angiography. At diagnosis, a median of 14.1 months had passed since first symptoms; 427 patients (62.9%) were considered operable, 247 (36.4%) nonoperable, and 5 (0.7%) had no operability data; 386 patients (56.8%, ranging from 12.0%-60.9% across countries) underwent surgery. Operable patients did not differ from nonoperable patients relative to symptoms, New York Heart Association class, and hemodynamics. A history of acute pulmonary embolism was reported for 74.8% of patients (77.5% operable, 70.0% nonoperable). Associated conditions included thrombophilic disorder in 31.9% (37.1% operable, 23.5% nonoperable) and splenectomy in 3.4% of patients (1.9% operable, 5.7% nonoperable). At the time of CTEPH diagnosis, 37.7% of patients initiated at least 1 pulmonary arterial hypertension-targeted therapy (28.3% operable, 53.8% nonoperable). Pulmonary endarterectomy was performed with a 4.7% documented mortality rate. Conclusions-Despite similarities in clinical presentation, operable and nonoperable CTEPH patients may have distinct associated medical conditions. Operability rates vary considerably across countries, and a substantial number of patients (operable and nonoperable) receive off-label pulmonary arterial hypertension-targeted treatments. (Circulation. 2011; 124: 1973-1981.) Background-Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel of venous thromboembolism with fatal natural history; however, many cases can be cured by pulmonary endarterectomy. The clinical characteristics and current management of patients enrolled in an international CTEPH registry was investigated. Methods and Results-The international registry included 679 newly diagnosed (<= 6 months) consecutive patients with CTEPH, from February 2007 until January 2009. Diagnosis was confirmed by right heart catheterization, ventilation-perfusion lung scintigraphy, computerized tomography, and/or pulmonary angiography. At diagnosis, a median of 14.1 months had passed since first symptoms; 427 patients (62.9%) were considered operable, 247 (36.4%) nonoperable, and 5 (0.7%) had no operability data; 386 patients (56.8%, ranging from 12.0%-60.9% across countries) underwent surgery. Operable patients did not differ from nonoperable patients relative to symptoms, New York Heart Association class, and hemodynamics. A history of acute pulmonary embolism was reported for 74.8% of patients (77.5% operable, 70.0% nonoperable). Associated conditions included thrombophilic disorder in 31.9% (37.1% operable, 23.5% nonoperable) and splenectomy in 3.4% of patients (1.9% operable, 5.7% nonoperable). At the time of CTEPH diagnosis, 37.7% of patients initiated at least 1 pulmonary arterial hypertension-targeted therapy (28.3% operable, 53.8% nonoperable). Pulmonary endarterectomy was performed with a 4.7% documented mortality rate. Conclusions-Despite similarities in clinical presentation, operable and nonoperable CTEPH patients may have distinct associated medical conditions. Operability rates vary considerably across countries, and a substantial number of patients (operable and nonoperable) receive off-label pulmonary arterial hypertension-targeted treatments. (Circulation. 2011; 124: 1973-1981.)
dcterms:title
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Results From an International Prospective Registry Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Results From an International Prospective Registry
skos:prefLabel
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Results From an International Prospective Registry Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Results From an International Prospective Registry
skos:notation
RIV/00064165:_____/11:9855!RIV12-MZ0-00064165
n11:predkladatel
n12:ico%3A00064165
n3:aktivita
n9:V
n3:aktivity
V
n3:cisloPeriodika
18
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n6:2475154 n6:7324049
n3:druhVysledku
n13:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
190347
n3:idVysledku
RIV/00064165:_____/11:9855
n3:jazykVysledku
n16:eng
n3:klicovaSlova
hypertension, pulmonary; endarterectomy; chronic disease; antiphospholipid antibodies; surgical-management; of-cardiology; risk-factors; task-force; follow-up; embolism; endarterectomy; thromboendarterectomy; thrombosis
n3:klicoveSlovo
n8:hypertension n8:thromboendarterectomy n8:thrombosis n8:antiphospholipid%20antibodies n8:task-force n8:risk-factors n8:pulmonary n8:follow-up n8:chronic%20disease n8:endarterectomy n8:surgical-management n8:embolism n8:of-cardiology
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[0ABE856D0C91]
n3:nazevZdroje
Circulation
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
25
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
124
n3:tvurceVysledku
Mayer, Eckhard Delcroix, Marion Morsolini, Marco Lang, Irene Pepke-Zaba, Joanna D\\\'Armini, Andrea M Snijder, Repke Ambrož, David Jansa, Pavel Treacy, Carmen
n3:wos
000296593800020
s:issn
0009-7322
s:numberOfPages
9