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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A9834%21RIV12-MZ0-00064165
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://fb.cuni.cz/file/5597/FB2011A0026.pdf
dcterms:description
Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH(2)-terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endocrine and neuroendocrine cells. The largest amount of CgA occurs in chromaffin granules of adrenal medulla and in the dense-core vesicles of sympathetic nerves. Its biological functions have not been completely elucidated, but it is known that it acts as a precursor of many biologically active peptides generated by cleavage at specific sites. It is the major soluble protein co-stored and co-released along with resident catecholamines and polypeptide hormones or cell-specific neurotransmitters. Because of its widespread distribution in neuroendocrine tissue, it can be used both as immunohistochemical marker and serum marker of neuroendocrine tumours. CgA has been used as a rather reliable tumour marker because its level is significantly increased in neuroendocrine tumours and changes of its level reflect the tumour response to therapy or tumour recurrence. Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH(2)-terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endocrine and neuroendocrine cells. The largest amount of CgA occurs in chromaffin granules of adrenal medulla and in the dense-core vesicles of sympathetic nerves. Its biological functions have not been completely elucidated, but it is known that it acts as a precursor of many biologically active peptides generated by cleavage at specific sites. It is the major soluble protein co-stored and co-released along with resident catecholamines and polypeptide hormones or cell-specific neurotransmitters. Because of its widespread distribution in neuroendocrine tissue, it can be used both as immunohistochemical marker and serum marker of neuroendocrine tumours. CgA has been used as a rather reliable tumour marker because its level is significantly increased in neuroendocrine tumours and changes of its level reflect the tumour response to therapy or tumour recurrence.
dcterms:title
Chromogranin A in Physiology and Oncology Chromogranin A in Physiology and Oncology
skos:prefLabel
Chromogranin A in Physiology and Oncology Chromogranin A in Physiology and Oncology
skos:notation
RIV/00064165:_____/11:9834!RIV12-MZ0-00064165
n14:predkladatel
n15:ico%3A00064165
n3:aktivita
n12:Z n12:I
n3:aktivity
I, Z(MSM0021620808)
n3:cisloPeriodika
5
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n6:2166526
n3:druhVysledku
n16:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
190335
n3:idVysledku
RIV/00064165:_____/11:9834
n3:jazykVysledku
n18:eng
n3:klicovaSlova
chromogranin; neuroendocrine tumours; cleavage fragments; extracellular functions; intracellular functions; tumour marker; neuroendocrine tumors; immunoradiometric assay; diagnosis; markers; pheochromocytoma; endocrine; fragments; neoplasia; granules; release
n3:klicoveSlovo
n7:immunoradiometric%20assay n7:tumour%20marker n7:neuroendocrine%20tumours n7:chromogranin n7:pheochromocytoma n7:cleavage%20fragments n7:granules n7:extracellular%20functions n7:markers n7:release n7:neoplasia n7:endocrine n7:diagnosis n7:intracellular%20functions n7:neuroendocrine%20tumors n7:fragments
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[205CFCD17F9C]
n3:nazevZdroje
Folia Biologica
n3:obor
n13:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
57
n3:tvurceVysledku
Louthan, Oldřich
n3:wos
000297182800001
n3:zamer
n17:MSM0021620808
s:issn
0015-5500
s:numberOfPages
9