This HTML5 document contains 55 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n5http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n9http://linked.opendata.cz/resource/domain/vavai/subjekt/
n8http://linked.opendata.cz/ontology/domain/vavai/
n17http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00064165%3A_____%2F11%3A9530%21RIV12-MZ0-00064165/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n14http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A9530%21RIV12-MZ0-00064165
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1365-2710.2010.01203.x
dcterms:description
What is known and Objective: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. Methods: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0.7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. Results and Discussion: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69.6% and mydriasis in 30.4% of the subjects. The pupillary response differed in relation to the CYP2D6 genotype. A maximal difference in initial pupil diameter of 0.81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0.05) except for the reflex amplitude and constriction velocity. What is new and Conclusion: The pharmacodynamic effects of tramadol were easily detected using both static and dynamic pupil parameters. The pharmacodynamic profiles were markedly influenced by the CYP2D6 phenotype. What is known and Objective: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. Methods: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0.7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. Results and Discussion: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69.6% and mydriasis in 30.4% of the subjects. The pupillary response differed in relation to the CYP2D6 genotype. A maximal difference in initial pupil diameter of 0.81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0.05) except for the reflex amplitude and constriction velocity. What is new and Conclusion: The pharmacodynamic effects of tramadol were easily detected using both static and dynamic pupil parameters. The pharmacodynamic profiles were markedly influenced by the CYP2D6 phenotype.
dcterms:title
Pupillometry in healthy volunteers as a biomarker of tramadol efficacy Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
skos:prefLabel
Pupillometry in healthy volunteers as a biomarker of tramadol efficacy Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
skos:notation
RIV/00064165:_____/11:9530!RIV12-MZ0-00064165
n8:predkladatel
n9:ico%3A00064165
n3:aktivita
n10:Z n10:I
n3:aktivity
I, Z(MSM0021620849)
n3:cisloPeriodika
4
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n5:5781752 n5:8883092 n5:8164401 n5:4294114
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
225276
n3:idVysledku
RIV/00064165:_____/11:9530
n3:jazykVysledku
n16:eng
n3:klicovaSlova
CYP2D6; pharmacodynamics; pharmacogenetics; pupillometry; tramadol; alzheimers-disease; cyp2d6 polymorphism; pupillary response; pharmacokinetics; morphine; tropicamide; light
n3:klicoveSlovo
n4:pharmacogenetics n4:pharmacokinetics n4:tropicamide n4:morphine n4:CYP2D6 n4:tramadol n4:light n4:alzheimers-disease n4:pupillary%20response n4:pupillometry n4:cyp2d6%20polymorphism n4:pharmacodynamics
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[C04038D1E068]
n3:nazevZdroje
Journal of Clinical Pharmacy and Therapeutics
n3:obor
n14:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
36
n3:tvurceVysledku
Perlík, František Slanař, Ondřej Chytil, Lukáš Matoušková, Olga
n3:wos
000292464300008
n3:zamer
n17:MSM0021620849
s:issn
0269-4727
s:numberOfPages
5