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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A9162%21RIV12-MZ0-00064165
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3109/0886022X.2010.541581
dcterms:description
Background: Advanced glycation end product (AGE) levels are elevated in patients with decreased renal function and may contribute to the excessive cardiovascular disease in this population. However, their relation to nutrition, anemia, and micro inflammation is not well characterized. The aim of this study is to determine their relationship in patients with chronic kidney disease (CKD). Methods: The studied group consisted of 203 subjects: 159 patients with CKD 1--5 and 44 healthy control subjects. AGE levels were assessed by spectrofluorimetry, and routine biochemical parameters were measured using standard methods. Results: AGE levels were significantly increased in CKD patients compared with controls (3.9 +/-+/- 1.7 xx 105 AU in CKD 1--5 patients vs. 3.2 +/-+/- 0.48 xx 105 AU in controls, p < 0.0001). AGE levels increased from CKD 3. AGE levels were positively associated with age, albumin, prealbumin, and orosomucoid, and were negatively associated with hemoglobin and estimated glomerular filtration rate. In multiple regression analysis, after adjustment to age and glomerular filtration rate, AGE levels remained independently correlated with albumin and prealbumin and negatively correlated with hemoglobin. Conclusions: This study is the demonstration that nutrition markers, albumin and prealbumin, are the positive determinants and hemoglobin is the negative determinant of serum AGE levels in patients with CKD. Background: Advanced glycation end product (AGE) levels are elevated in patients with decreased renal function and may contribute to the excessive cardiovascular disease in this population. However, their relation to nutrition, anemia, and micro inflammation is not well characterized. The aim of this study is to determine their relationship in patients with chronic kidney disease (CKD). Methods: The studied group consisted of 203 subjects: 159 patients with CKD 1--5 and 44 healthy control subjects. AGE levels were assessed by spectrofluorimetry, and routine biochemical parameters were measured using standard methods. Results: AGE levels were significantly increased in CKD patients compared with controls (3.9 +/-+/- 1.7 xx 105 AU in CKD 1--5 patients vs. 3.2 +/-+/- 0.48 xx 105 AU in controls, p < 0.0001). AGE levels increased from CKD 3. AGE levels were positively associated with age, albumin, prealbumin, and orosomucoid, and were negatively associated with hemoglobin and estimated glomerular filtration rate. In multiple regression analysis, after adjustment to age and glomerular filtration rate, AGE levels remained independently correlated with albumin and prealbumin and negatively correlated with hemoglobin. Conclusions: This study is the demonstration that nutrition markers, albumin and prealbumin, are the positive determinants and hemoglobin is the negative determinant of serum AGE levels in patients with CKD.
dcterms:title
Associations of Serum Levels of Advanced Glycation end Products with Nutrition Markers and Anemia in Patients with Chronic Kidney Disease Associations of Serum Levels of Advanced Glycation end Products with Nutrition Markers and Anemia in Patients with Chronic Kidney Disease
skos:prefLabel
Associations of Serum Levels of Advanced Glycation end Products with Nutrition Markers and Anemia in Patients with Chronic Kidney Disease Associations of Serum Levels of Advanced Glycation end Products with Nutrition Markers and Anemia in Patients with Chronic Kidney Disease
skos:notation
RIV/00064165:_____/11:9162!RIV12-MZ0-00064165
n13:predkladatel
n14:ico%3A00064165
n3:aktivita
n12:Z n12:I n12:S
n3:aktivity
I, S, Z(MSM0021620807)
n3:cisloPeriodika
2
n3:dodaniDat
n7:2012
n3:domaciTvurceVysledku
n10:8705097 n10:5909627 n10:8684731 n10:6377165
n3:druhVysledku
n19:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
187340
n3:idVysledku
RIV/00064165:_____/11:9162
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Chronic kidney disease; advanced glycation end products; nutrition; anemia; atherosclerosis; AGEs; IgA; oxidative stress; albumin; preambulin
n3:klicoveSlovo
n9:IgA n9:Chronic%20kidney%20disease n9:anemia n9:preambulin n9:albumin n9:oxidative%20stress n9:advanced%20glycation%20end%20products n9:atherosclerosis n9:AGEs n9:nutrition
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3438F430D69A]
n3:nazevZdroje
Renal Failure
n3:obor
n15:FE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n7:2011
n3:svazekPeriodika
33
n3:tvurceVysledku
Tesař, Vladimír Kratochvílová, Markéta Zakiyanov, Oskar Zima, Tomáš Kříha, Vítězslav Kalousová, Marta
n3:wos
000287485800004
n3:zamer
n18:MSM0021620807
s:issn
0886-022X
s:numberOfPages
7