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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A8770%21RIV12-MZ0-00064165
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1159/000322994
dcterms:description
Background: Diabetic retinopathy (DR) is characterized by blood-retina barrier breakdown induced by local changes in the retina and systemic factors. We investigated vitreous and serum levels of glucose and uric acid (UA) in patients with DR and aimed to describe their correlation with the grade of DR. Methods: Prospective study of 81 patients with DR and 48 non-diabetic controls. Biochemical analysis of vitreous and serum samples was performed. Results: UA and glucose concentrations in vitreous and serum were significantly higher in diabetic patients than in controls. Absolute ratios (vitreous level/serum level) of UA and glucose were higher in proliferative compared with non-proliferative DR. Conclusions: The results suggest that, apart from glucose, increased levels of UA in diabetic patients may also be involved in the pathogenesis and progression of DR. Background: Diabetic retinopathy (DR) is characterized by blood-retina barrier breakdown induced by local changes in the retina and systemic factors. We investigated vitreous and serum levels of glucose and uric acid (UA) in patients with DR and aimed to describe their correlation with the grade of DR. Methods: Prospective study of 81 patients with DR and 48 non-diabetic controls. Biochemical analysis of vitreous and serum samples was performed. Results: UA and glucose concentrations in vitreous and serum were significantly higher in diabetic patients than in controls. Absolute ratios (vitreous level/serum level) of UA and glucose were higher in proliferative compared with non-proliferative DR. Conclusions: The results suggest that, apart from glucose, increased levels of UA in diabetic patients may also be involved in the pathogenesis and progression of DR.
dcterms:title
Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema
skos:prefLabel
Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema
skos:notation
RIV/00064165:_____/11:8770!RIV12-MZ0-00064165
n15:predkladatel
n19:ico%3A00064165
n4:aktivita
n10:Z n10:I
n4:aktivity
I, Z(MSM0021620807)
n4:cisloPeriodika
2
n4:dodaniDat
n7:2012
n4:domaciTvurceVysledku
n5:5183251 n5:8002177 n5:8762597 n5:8705097 n5:5489210 n5:6377165
n4:druhVysledku
n12:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
204114
n4:idVysledku
RIV/00064165:_____/11:8770
n4:jazykVysledku
n16:eng
n4:klicovaSlova
Vitreous; Diabetic retinopathy; Diabetic macular oedema; Uric acid; Glucose
n4:klicoveSlovo
n8:Diabetic%20retinopathy n8:Vitreous n8:Diabetic%20macular%20oedema n8:Glucose n8:Uric%20acid
n4:kodStatuVydavatele
CH - Švýcarská konfederace
n4:kontrolniKodProRIV
[2EA97F43AF64]
n4:nazevZdroje
Ophthalmic Research
n4:obor
n11:FF
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n7:2011
n4:svazekPeriodika
46
n4:tvurceVysledku
Kuběna, A. Zima, Tomáš Kalvoda, Jan Křížová, L. Kalousová, Marta Kovařík, Zdeněk Kalvodová, Bohdana Benáková, Hana
n4:wos
000293266200003
n4:zamer
n14:MSM0021620807
s:issn
0030-3747
s:numberOfPages
7