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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A10148%21RIV12-MZ0-00064165
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1600-0412.2011.01114.x
dcterms:description
A recently published meta-analysis of 21 studies confirmed a protective effect of tubal ligation on the risk of invasive ovarian cancer. This protective measure has received little attention, particularly due to the elusive underlying mechanism. In this commentary we discuss available data concerning the contribution of different potential mechanisms by which tubal ligation might prevent ovarian cancer. Included were studies published in English, identified through a literature search using PubMed and EMBASE. Four main mechanisms are discussed: (a) a screening effect, (b) alteration of ovarian function, (c) a mechanical barrier against ascending carcinogenic agents and (d) prevention of endometrial and proximal Fallopian tube cell ascent. There are arguments supporting the major role of a mechanical barrier to the ascent of endometrial cells into the peritoneal cavity for decreasing risk of ovarian cancer after tubal ligation. Prevention of retrograde transport of carcinogenic substances from the vagina may be an additional mechanism. A recently published meta-analysis of 21 studies confirmed a protective effect of tubal ligation on the risk of invasive ovarian cancer. This protective measure has received little attention, particularly due to the elusive underlying mechanism. In this commentary we discuss available data concerning the contribution of different potential mechanisms by which tubal ligation might prevent ovarian cancer. Included were studies published in English, identified through a literature search using PubMed and EMBASE. Four main mechanisms are discussed: (a) a screening effect, (b) alteration of ovarian function, (c) a mechanical barrier against ascending carcinogenic agents and (d) prevention of endometrial and proximal Fallopian tube cell ascent. There are arguments supporting the major role of a mechanical barrier to the ascent of endometrial cells into the peritoneal cavity for decreasing risk of ovarian cancer after tubal ligation. Prevention of retrograde transport of carcinogenic substances from the vagina may be an additional mechanism.
dcterms:title
Underlying mechanisms of ovarian cancer risk reduction after tubal ligation Underlying mechanisms of ovarian cancer risk reduction after tubal ligation
skos:prefLabel
Underlying mechanisms of ovarian cancer risk reduction after tubal ligation Underlying mechanisms of ovarian cancer risk reduction after tubal ligation
skos:notation
RIV/00064165:_____/11:10148!RIV12-MZ0-00064165
n8:predkladatel
n12:ico%3A00064165
n3:aktivita
n17:V
n3:aktivity
V
n3:cisloPeriodika
6
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n5:3492125 n5:3630501
n3:druhVysledku
n18:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
236792
n3:idVysledku
RIV/00064165:_____/11:10148
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Cancer prevention; ovarian cancer; tubal ligation; states case-control; collaborative analysis; reproductive history; epithelial tumors; cosmetic talc; white women; sterilization; hysterectomy; carcinoma; exposure
n3:klicoveSlovo
n6:collaborative%20analysis n6:ovarian%20cancer n6:cosmetic%20talc n6:white%20women n6:carcinoma n6:tubal%20ligation n6:sterilization n6:states%20case-control n6:reproductive%20history n6:hysterectomy n6:Cancer%20prevention n6:epithelial%20tumors n6:exposure
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[9032B2CBE877]
n3:nazevZdroje
Acta Obstetricia et Gynecologica Scandinavica
n3:obor
n7:FK
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
90
n3:tvurceVysledku
Zikán, Michal Widschwendter, M. Cibula, David Dušek, L.
n3:wos
000291433600002
s:issn
0001-6349
s:numberOfPages
5