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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F11%3A%230000016%21RIV12-MPS-00064165
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders. Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders.
dcterms:title
Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders
skos:prefLabel
Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders
skos:notation
RIV/00064165:_____/11:#0000016!RIV12-MPS-00064165
n10:predkladatel
n11:ico%3A00064165
n3:aktivita
n15:V n15:I n15:P
n3:aktivity
I, P(HC 202/2010), V
n3:cisloPeriodika
17
n3:dodaniDat
n8:2012
n3:domaciTvurceVysledku
n13:8985049 n13:3878392
n3:druhVysledku
n18:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
195304
n3:idVysledku
RIV/00064165:_____/11:#0000016
n3:jazykVysledku
n4:eng
n3:klicovaSlova
psychopathology; genetics; dopamine
n3:klicoveSlovo
n5:dopamine n5:genetics n5:psychopathology
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EF71CCF365C1]
n3:nazevZdroje
Medical Science Monitor
n3:obor
n16:FL
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n17:HC%20202%2F2010
n3:rokUplatneniVysledku
n8:2011
n3:svazekPeriodika
2011
n3:tvurceVysledku
Ptáček, Radek Stefano, George B. Kuželová, Hana
s:issn
1643-3750
s:numberOfPages
5