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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F10%3A6753%21RIV11-MZ0-00064165
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness. Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset. The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin. Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness. Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset. The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin.
dcterms:title
Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
skos:prefLabel
Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
skos:notation
RIV/00064165:_____/10:6753!RIV11-MZ0-00064165
n3:aktivita
n13:I n13:Z
n3:aktivity
I, Z(MSM0021620849)
n3:cisloPeriodika
7
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n14:5374677
n3:druhVysledku
n15:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
247170
n3:idVysledku
RIV/00064165:_____/10:6753
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Human narcolepsy; Tribbles homolog 2 (TRIB2); autoantibody; anti-streptolysin O (ASO); hypocretin orexin; antibodies; diagnosis; sleep; mutation; uveitis; assay
n3:klicoveSlovo
n8:antibodies n8:Tribbles%20homolog%202%20%28TRIB2%29 n8:assay n8:Human%20narcolepsy n8:anti-streptolysin%20O%20%28ASO%29 n8:autoantibody n8:mutation n8:uveitis n8:hypocretin%20orexin n8:diagnosis n8:sleep
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C3C9B437883A]
n3:nazevZdroje
Sleep
n3:obor
n12:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
33
n3:tvurceVysledku
Jennum, Poul Mignot, Emmanuel Lin, Ling Kawashima, Minae Nevšímalová, Soňa Tanaka, Susumu Knudsen, Stine Plazzi, Giuseppe
n3:wos
000279365600006
n3:zamer
n11:MSM0021620849
s:issn
0161-8105
s:numberOfPages
6