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Statements

Subject Item
n2:RIV%2F00064165%3A_____%2F09%3A4602%21RIV10-MZ0-00064165
rdf:type
n12:Vysledek skos:Concept
dcterms:description
DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets. DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets.
dcterms:title
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study
skos:prefLabel
HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study
skos:notation
RIV/00064165:_____/09:4602!RIV10-MZ0-00064165
n3:aktivita
n13:N
n3:aktivity
N
n3:cisloPeriodika
1
n3:dodaniDat
n10:2010
n3:domaciTvurceVysledku
n15:3492125
n3:druhVysledku
n14:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
317891
n3:idVysledku
RIV/00064165:_____/09:4602
n3:jazykVysledku
n16:eng
n3:klicovaSlova
ovarian cancer; methylation; HOXA; Mullerian duct; endometrium
n3:klicoveSlovo
n6:Mullerian%20duct n6:methylation n6:HOXA n6:ovarian%20cancer n6:endometrium
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[9EBDF11455A3]
n3:nazevZdroje
International Journal of Cancer
n3:obor
n5:FK
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
17
n3:rokUplatneniVysledku
n10:2009
n3:svazekPeriodika
125
n3:tvurceVysledku
Arora, Rupali Ayhan, Ayse Frasco, Melissa A. Zikán, Michal Pearce, Celeste Leigh Widschwendter, Martin Fourkala, Evangelia O. Jones, Allison A. Apostolidou, Sophia
n3:wos
000270750000029
s:issn
0020-7136
s:numberOfPages
5