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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F14%3A%230001177%21RIV15-MZE-00027162
rdf:type
n13:Vysledek skos:Concept
dcterms:description
Phthalate esters are ubiquitous environmental pollutants widely used as plasticizers, which have been shown to interfere with both endocrine regulation and development of reproductive organs. In the present study, we examined the impact of diethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) on the proliferation of androgen-sensitive human prostate carcinoma LNCaP cells and related events. The results showed that both compounds were able to inhibit cell cycle progression in a dose-dependent manner. However, only DEHP was found to weakly reduce androgen receptor (AR) protein levels after long-term exposure, while only DBP partially inhibited expression of the prostate-specific antigen (KLK3) gene, a model AR transcriptional target. This indicated that inhibition of cell proliferation was likely independent of any AR modulations. Both phthalates induced suppression of cell proliferation, but none of them affected the levels of markers associated with neuroendocrine transdifferentiation (NED) in LNCaP cells. Taken together, the presented data indicate that phthalates may exert long-term negative effects on the proliferation of prostate epithelial cells derived from the carcinoma model, which are, nevertheless, largely independent of the modulation of AR expression/activity, and which do not alter further processes associated with NED. Phthalate esters are ubiquitous environmental pollutants widely used as plasticizers, which have been shown to interfere with both endocrine regulation and development of reproductive organs. In the present study, we examined the impact of diethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP) on the proliferation of androgen-sensitive human prostate carcinoma LNCaP cells and related events. The results showed that both compounds were able to inhibit cell cycle progression in a dose-dependent manner. However, only DEHP was found to weakly reduce androgen receptor (AR) protein levels after long-term exposure, while only DBP partially inhibited expression of the prostate-specific antigen (KLK3) gene, a model AR transcriptional target. This indicated that inhibition of cell proliferation was likely independent of any AR modulations. Both phthalates induced suppression of cell proliferation, but none of them affected the levels of markers associated with neuroendocrine transdifferentiation (NED) in LNCaP cells. Taken together, the presented data indicate that phthalates may exert long-term negative effects on the proliferation of prostate epithelial cells derived from the carcinoma model, which are, nevertheless, largely independent of the modulation of AR expression/activity, and which do not alter further processes associated with NED.
dcterms:title
Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model
skos:prefLabel
Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model Phthalates Deregulate Cell Proliferation, but Not Neuroendocrine Transdifferentiation, in Human LNCaP Prostate Cancer Cell Model
skos:notation
RIV/00027162:_____/14:#0001177!RIV15-MZE-00027162
n5:aktivita
n12:I n12:N n12:P
n5:aktivity
I, N, P(ED1.100/02/0123), P(EE2.3.30.0030)
n5:cisloPeriodika
2014
n5:dodaniDat
n7:2015
n5:domaciTvurceVysledku
n16:5686350 n16:4363744
n5:druhVysledku
n15:J
n5:duvernostUdaju
n10:S
n5:entitaPredkladatele
n14:predkladatel
n5:idSjednocenehoVysledku
36533
n5:idVysledku
RIV/00027162:_____/14:#0001177
n5:jazykVysledku
n17:eng
n5:klicovaSlova
phthalates; prostate cancer cells; cell cycle modulation; neuroendocrine transdifferentiation; androgen receptor
n5:klicoveSlovo
n8:cell%20cycle%20modulation n8:neuroendocrine%20transdifferentiation n8:phthalates n8:prostate%20cancer%20cells n8:androgen%20receptor
n5:kodStatuVydavatele
CZ - Česká republika
n5:kontrolniKodProRIV
[A57407AF0D04]
n5:nazevZdroje
Folia Biologica
n5:obor
n11:CE
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
6
n5:projekt
n9:EE2.3.30.0030 n9:ED1.100%2F02%2F0123
n5:rokUplatneniVysledku
n7:2014
n5:svazekPeriodika
60
n5:tvurceVysledku
Vondráček, J. Hrubá, E. Machala, Miroslav Souček, K. Pálková, Lenka Pernicová, Z.
n5:wos
000343275800009
s:issn
0015-5500
s:numberOfPages
6