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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F14%3A%230001136%21RIV15-MSM-00027162
rdf:type
skos:Concept n16:Vysledek
dcterms:description
This study aims to investigate the anti-inflammatory effect of biologically active phospholipids (BAP) used in preparations for clinical practice in humans. Until date, except anti-neoplastic ability, little is known about anti-inflammatory property of the phospholipids. While the course of bacterially induced acute pneumonia and markers of inflammation were studied in in vivo system in pigs orally supplemented with BAP, the pro- and anti-inflammatory response of lipopolysaccharide-stimulated porcine monocyte-derived macrophages to 24 h- and 48 h-treatmeant by BAP was investigated in in vitro system. In vivo, the animal health status was monitored and pro-inflammatory IL-1 beta and IL-8 in sera were detected by ELISA during the experiment, while bronchoalveolar lavage fluids (BALF) and the lungs were examined post-mortem. Total and differential counts of white blood cell (WBC) were determined in blood and BALF. In vitro, mRNA expression of pro-inflammatory (TNF-alpha, IL-1 beta, CXCL10) and anti-inflammatory (IL-10 and Arg1) cytokines, and level of activated caspase 1 and phosphorylated protein kinase C epsilon (pPKC epsilon), were studied using qRT-PCR and Western blot, respectively. For the purposes of both systems, 6 animals were used in each of the BAP-supplemented and the control groups. Our results demonstrate that BAP has anti-inflammatory and immunomodulatory properties, thus emphasizing the potential of this compound as a natural healing agent. This study aims to investigate the anti-inflammatory effect of biologically active phospholipids (BAP) used in preparations for clinical practice in humans. Until date, except anti-neoplastic ability, little is known about anti-inflammatory property of the phospholipids. While the course of bacterially induced acute pneumonia and markers of inflammation were studied in in vivo system in pigs orally supplemented with BAP, the pro- and anti-inflammatory response of lipopolysaccharide-stimulated porcine monocyte-derived macrophages to 24 h- and 48 h-treatmeant by BAP was investigated in in vitro system. In vivo, the animal health status was monitored and pro-inflammatory IL-1 beta and IL-8 in sera were detected by ELISA during the experiment, while bronchoalveolar lavage fluids (BALF) and the lungs were examined post-mortem. Total and differential counts of white blood cell (WBC) were determined in blood and BALF. In vitro, mRNA expression of pro-inflammatory (TNF-alpha, IL-1 beta, CXCL10) and anti-inflammatory (IL-10 and Arg1) cytokines, and level of activated caspase 1 and phosphorylated protein kinase C epsilon (pPKC epsilon), were studied using qRT-PCR and Western blot, respectively. For the purposes of both systems, 6 animals were used in each of the BAP-supplemented and the control groups. Our results demonstrate that BAP has anti-inflammatory and immunomodulatory properties, thus emphasizing the potential of this compound as a natural healing agent.
dcterms:title
Evaluation of in vitro and in vivo anti-inflammatory activity of biologically active phospholipids with anti-neoplastic potential in porcine model Evaluation of in vitro and in vivo anti-inflammatory activity of biologically active phospholipids with anti-neoplastic potential in porcine model
skos:prefLabel
Evaluation of in vitro and in vivo anti-inflammatory activity of biologically active phospholipids with anti-neoplastic potential in porcine model Evaluation of in vitro and in vivo anti-inflammatory activity of biologically active phospholipids with anti-neoplastic potential in porcine model
skos:notation
RIV/00027162:_____/14:#0001136!RIV15-MSM-00027162
n3:aktivita
n15:P
n3:aktivity
P(LO1218)
n3:cisloPeriodika
339
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n8:7331614 n8:3079562 n8:6502415 n8:7153643 n8:5520126 n8:2759411 n8:9627650
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
15375
n3:idVysledku
RIV/00027162:_____/14:#0001136
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Inflammation; Lipopolysaccharide; Porcine model; Macrophages; Ether phospholipids
n3:klicoveSlovo
n6:Porcine%20model n6:Macrophages n6:Lipopolysaccharide n6:Ether%20phospholipids n6:Inflammation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[ABEF79BA9AC5]
n3:nazevZdroje
BMC Complementary and Alternative Medicine
n3:obor
n14:GJ
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n18:LO1218
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
14
n3:tvurceVysledku
Faldyna, Martin Štěpánová, Hana Vícenová, Monika Kučerová, Zdeňka Nechvátalová, Kateřina Levá, Lenka Chlebová, Katarína
n3:wos
000342646400001
s:issn
1472-6882
s:numberOfPages
10
n10:doi
10.1186/1472-6882-14-339