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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F14%3A%230001107%21RIV15-MSM-00027162
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Globozoospermia, characterised by the presence of round spermatozoa lacking acrosomes in an ejaculate, is a known cause of male infertility. Semen analysis, including sperm chromatin structure assay, toluidine blue, chromomycin A3 and aniline blue staining and fluorescence in situ hybridisation, was performed in an infertile globozoospermic patient to establish to which extent these genetic factors contributed to his infertility. No spermatozoa capable of hyaluronan (HA) binding were detected in the HA binding assay. Increased rates of immature spermatozoa with defective replacement of histones by protamines, DNA breaks and disturbed chromatin integrity and sperm aneuploid for the sex chromosomes were observed. Intracytoplasmic sperm injection (ICSI) was used in three in vitro fertilisation (IVF) cycles, and enough morphologically well-developing embryos were obtained in each cycle. However, no pregnancy was achieved. The infertility of our couple, resistant to IVF/ICSI treatment, was most probably caused by a combination of male and female factors. Globozoospermia, characterised by the presence of round spermatozoa lacking acrosomes in an ejaculate, is a known cause of male infertility. Semen analysis, including sperm chromatin structure assay, toluidine blue, chromomycin A3 and aniline blue staining and fluorescence in situ hybridisation, was performed in an infertile globozoospermic patient to establish to which extent these genetic factors contributed to his infertility. No spermatozoa capable of hyaluronan (HA) binding were detected in the HA binding assay. Increased rates of immature spermatozoa with defective replacement of histones by protamines, DNA breaks and disturbed chromatin integrity and sperm aneuploid for the sex chromosomes were observed. Intracytoplasmic sperm injection (ICSI) was used in three in vitro fertilisation (IVF) cycles, and enough morphologically well-developing embryos were obtained in each cycle. However, no pregnancy was achieved. The infertility of our couple, resistant to IVF/ICSI treatment, was most probably caused by a combination of male and female factors.
dcterms:title
Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report
skos:prefLabel
Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report Total globozoospermia associated with increased frequency of immature spermatozoa with chromatin defects and aneuploidy: a case report
skos:notation
RIV/00027162:_____/14:#0001107!RIV15-MSM-00027162
n4:aktivita
n16:P
n4:aktivity
P(ED1.1.00/02.0068)
n4:cisloPeriodika
8
n4:dodaniDat
n17:2015
n4:domaciTvurceVysledku
n9:7029217 n9:8164703 n9:8767246 n9:9185682
n4:druhVysledku
n18:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
50741
n4:idVysledku
RIV/00027162:_____/14:#0001107
n4:jazykVysledku
n14:eng
n4:klicovaSlova
Aneuploidy; chromatin integrity; globozoospermia; infertility; sperm maturation
n4:klicoveSlovo
n5:infertility n5:sperm%20maturation n5:globozoospermia n5:Aneuploidy n5:chromatin%20integrity
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[9E0EA2FF0F7C]
n4:nazevZdroje
Andrologia
n4:obor
n7:EB
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
6
n4:projekt
n11:ED1.1.00%2F02.0068
n4:rokUplatneniVysledku
n17:2014
n4:svazekPeriodika
46
n4:tvurceVysledku
Přinosilová, Petra Kloudová, S. Rubeš, Jiří Vozdová, Miluše Rybář, Roman Texl, P.
n4:wos
000342811000003
s:issn
0303-4569
s:numberOfPages
6
n15:doi
10.1111/and.12156