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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F13%3A%230000972%21RIV14-MZE-00027162
rdf:type
skos:Concept n5:Vysledek
dcterms:description
The present study describes the distinct bone marrow (BM) and peripheral blood (PB) monocyte subpopulations detected by seven-colour flow cytometry. Mononuclear phagocytes were identified as viable CD172a(+) SWC8(-) CD203a(-) mononuclear leukocytes. After that, monocyte subpopulations were differentiated by using CD14, CD163 and SLA-DR markers. Four distinct monocyte subpopulations were found in the BM and PB. Based on the discovered populations two possible maturation pathways have been proposed. The first pathway was characterised by release of CD14(hi) CD163(-) SLA-DR(-) BM monocytes into the PB where they matured into CD14(low) CD163(+) SLA-DR(+) monocytes. In the alternative pathway the monocytes finalised their phenotypical maturation in the BM and then they were released into the PB as CD14(low) CD163(+) SLA-DR(+) cells. In Salmonella-infected piglets, the population of CD14(low) CD163(+) SLA-DR(+) monocytes was elevated in the BM and mesenteric lymph nodes (MLN), suggesting the role of this population in pathogenesis of Salmonella infection in pigs. The present study describes the distinct bone marrow (BM) and peripheral blood (PB) monocyte subpopulations detected by seven-colour flow cytometry. Mononuclear phagocytes were identified as viable CD172a(+) SWC8(-) CD203a(-) mononuclear leukocytes. After that, monocyte subpopulations were differentiated by using CD14, CD163 and SLA-DR markers. Four distinct monocyte subpopulations were found in the BM and PB. Based on the discovered populations two possible maturation pathways have been proposed. The first pathway was characterised by release of CD14(hi) CD163(-) SLA-DR(-) BM monocytes into the PB where they matured into CD14(low) CD163(+) SLA-DR(+) monocytes. In the alternative pathway the monocytes finalised their phenotypical maturation in the BM and then they were released into the PB as CD14(low) CD163(+) SLA-DR(+) cells. In Salmonella-infected piglets, the population of CD14(low) CD163(+) SLA-DR(+) monocytes was elevated in the BM and mesenteric lymph nodes (MLN), suggesting the role of this population in pathogenesis of Salmonella infection in pigs.
dcterms:title
Phenotypic characterisation of the monocyte subpopulations in healthy adult pigs and Salmonella-infected piglets by seven-colour flow cytometry Phenotypic characterisation of the monocyte subpopulations in healthy adult pigs and Salmonella-infected piglets by seven-colour flow cytometry
skos:prefLabel
Phenotypic characterisation of the monocyte subpopulations in healthy adult pigs and Salmonella-infected piglets by seven-colour flow cytometry Phenotypic characterisation of the monocyte subpopulations in healthy adult pigs and Salmonella-infected piglets by seven-colour flow cytometry
skos:notation
RIV/00027162:_____/13:#0000972!RIV14-MZE-00027162
n5:predkladatel
n6:ico%3A00027162
n3:aktivita
n13:P n13:Z
n3:aktivity
P(ED0006/01/01), P(GA524/08/1606), P(GPP502/10/P362), Z(MZE0002716202)
n3:cisloPeriodika
2
n3:dodaniDat
n18:2014
n3:domaciTvurceVysledku
n7:5548721 n7:7362366 n7:7153643 n7:9736948
n3:druhVysledku
n8:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
96040
n3:idVysledku
RIV/00027162:_____/13:#0000972
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Monocyte subpopulations; Pig; Salmonella; Zenon labelling
n3:klicoveSlovo
n10:Zenon%20labelling n10:Pig n10:Monocyte%20subpopulations n10:Salmonella
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[6680794A4D36]
n3:nazevZdroje
RESEARCH IN VETERINARY SCIENCE
n3:obor
n20:EC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n4:GA524%2F08%2F1606 n4:GPP502%2F10%2FP362 n4:ED0006%2F01%2F01
n3:rokUplatneniVysledku
n18:2013
n3:svazekPeriodika
94
n3:tvurceVysledku
Dominguez, J. Faldyna, Martin Ondráčková, Petra Volf, Jiří Matiašovic, Ján
n3:wos
000316039300009
n3:zamer
n12:MZE0002716202
s:issn
0034-5288
s:numberOfPages
6
n19:doi
10.1016/j.rvsc.2012.09.006