This HTML5 document contains 54 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n18http://linked.opendata.cz/resource/domain/vavai/projekt/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n10http://linked.opendata.cz/resource/domain/vavai/subjekt/
n9http://linked.opendata.cz/ontology/domain/vavai/
n14http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00027162%3A_____%2F13%3A%230000960%21RIV14-MZE-00027162/
n20http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n4http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n19http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F13%3A%230000960%21RIV14-MZE-00027162
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The study investigated the effects of postnatal exposure to polycyclic aromatic hydrocarbons (PAHs) on the development of the rat ovary. Neonates were injected on each postnatal day 1-14 with benzo(a) pyrene (BaP), benz(a) anthracene (BaA) and benzo(k) fluoranthene (BkF) (0.1, 1.0, 5.0 or 10.0mg kg(-1)), ethynylestradiol (EE; 1.0 mu g kg(-1)) or a vehicle (control group). The rats were killed on day 23. Postnatal exposure to BaP increased the total number of antral follicles in ovaries and the number of nonatretic follicles as a result of a lower degree of apoptosis of granulosa cells, and the thickness of theca cell layers. Similar histological findings were observed after BaA administration. Conversely, BkF exposure caused a decrease in the number of antral follicles, but did not alter the other investigated parameters. Degeneration of primordial oocytes after exposure to PAHs was observed only after exposure to BaP. Treatment with BaP at doses of 1.0 and 10.0 mg kg(-1) impaired 28.1 and 60.3 of the primordial follicles, respectively. Substantial alterations in ovarian ER beta expression were detected in the rats; their intensity differed with the type of PAH. Response of the ovaries to EE (three injections of 1.0 mu g kg(-1) on postnatal days 20-22) in rats exposed to PAHs was suppressed in contrast to the controls. The study showed that postnatal exposure to BaP, BaA and BkF altered ovarian ER beta expression, disturbed morphological development of the ovaries and caused ovarian dysfunction in immature rats. The study investigated the effects of postnatal exposure to polycyclic aromatic hydrocarbons (PAHs) on the development of the rat ovary. Neonates were injected on each postnatal day 1-14 with benzo(a) pyrene (BaP), benz(a) anthracene (BaA) and benzo(k) fluoranthene (BkF) (0.1, 1.0, 5.0 or 10.0mg kg(-1)), ethynylestradiol (EE; 1.0 mu g kg(-1)) or a vehicle (control group). The rats were killed on day 23. Postnatal exposure to BaP increased the total number of antral follicles in ovaries and the number of nonatretic follicles as a result of a lower degree of apoptosis of granulosa cells, and the thickness of theca cell layers. Similar histological findings were observed after BaA administration. Conversely, BkF exposure caused a decrease in the number of antral follicles, but did not alter the other investigated parameters. Degeneration of primordial oocytes after exposure to PAHs was observed only after exposure to BaP. Treatment with BaP at doses of 1.0 and 10.0 mg kg(-1) impaired 28.1 and 60.3 of the primordial follicles, respectively. Substantial alterations in ovarian ER beta expression were detected in the rats; their intensity differed with the type of PAH. Response of the ovaries to EE (three injections of 1.0 mu g kg(-1) on postnatal days 20-22) in rats exposed to PAHs was suppressed in contrast to the controls. The study showed that postnatal exposure to BaP, BaA and BkF altered ovarian ER beta expression, disturbed morphological development of the ovaries and caused ovarian dysfunction in immature rats.
dcterms:title
Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons
skos:prefLabel
Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons Ovarian disorders in immature rats after postnatal exposure to environmental polycyclic aromatic hydrocarbons
skos:notation
RIV/00027162:_____/13:#0000960!RIV14-MZE-00027162
n9:predkladatel
n10:ico%3A00027162
n3:aktivita
n16:P n16:Z
n3:aktivity
P(ED0006/01/01), Z(MZE0002716202)
n3:cisloPeriodika
2
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n6:2563177 n6:7988370 n6:7153643 n6:3923673
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
94914
n3:idVysledku
RIV/00027162:_____/13:#0000960
n3:jazykVysledku
n13:eng
n3:klicovaSlova
ESTROGEN-RECEPTOR-ALPHA; REPORTER GENE ASSAY; FOLLICLE GROWTH; GRANULOSA-CELLS; MURINE OVARIAN; MCF-7 CELLS; FEMALE RAT; EXPRESSION; BENZO(A)PYRENE; BETA
n3:klicoveSlovo
n4:MURINE%20OVARIAN n4:ESTROGEN-RECEPTOR-ALPHA n4:FEMALE%20RAT n4:FOLLICLE%20GROWTH n4:GRANULOSA-CELLS n4:REPORTER%20GENE%20ASSAY n4:MCF-7%20CELLS n4:EXPRESSION n4:BENZO%28A%29PYRENE n4:BETA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A18FF8F31896]
n3:nazevZdroje
JOURNAL OF APPLIED TOXICOLOGY
n3:obor
n5:DN
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:ED0006%2F01%2F01
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
33
n3:tvurceVysledku
Faldyna, Martin Kummer, Vladimír Zralý, Zdeněk Mašková, Jarmila
n3:wos
000314069700002
n3:zamer
n14:MZE0002716202
s:issn
0260-437X
s:numberOfPages
10
n20:doi
10.1002/jat.1714