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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F12%3A%230000936%21RIV13-MZE-00027162
rdf:type
n11:Vysledek skos:Concept
dcterms:description
The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.
dcterms:title
Cyclin K goes with Cdk12 and Cdk13 Cyclin K goes with Cdk12 and Cdk13
skos:prefLabel
Cyclin K goes with Cdk12 and Cdk13 Cyclin K goes with Cdk12 and Cdk13
skos:notation
RIV/00027162:_____/12:#0000936!RIV13-MZE-00027162
n11:predkladatel
n17:ico%3A00027162
n3:aktivita
n12:Z n12:P
n3:aktivity
P(ED1.1.00/02.0068), P(GAP305/11/1564), Z(MZE0002716202)
n3:cisloPeriodika
12
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n18:6878393
n3:druhVysledku
n19:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
129349
n3:idVysledku
RIV/00027162:_____/12:#0000936
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2
n3:klicoveSlovo
n8:P-TEFb n8:Cyclin%20L n8:CTD%20kinase n8:Transcription n8:Phosphorylation%20of%20serine%202 n8:ATR n8:DNA%20damage n8:BRCA1 n8:FANCD2 n8:FANCI n8:CTD%20code n8:Posttranscriptional%20processing
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[3FB2A0562AD0]
n3:nazevZdroje
Cell Division
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:projekt
n7:ED1.1.00%2F02.0068 n7:GAP305%2F11%2F1564
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Kohoutek, Jiří Blažek, D.
n3:wos
000303827600001
n3:zamer
n15:MZE0002716202
s:issn
1747-1028
s:numberOfPages
11
n16:doi
10.1186/1747-1028-7-12