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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F12%3A%230000931%21RIV13-MZE-00027162
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents. Due to their unique characteristics, such as low molecular weight, high physical-chemical stability, good water solubility, and the ability to bind antigens inaccessible to conventional antibodies, they could potentially act as a substitute for conventional therapeutic drugs in the treatment of serious human diseases, and, moreover, could be broadly used in analyses and diagnostics. In this review article, an analysis of 826 publications oriented to heavy-chain antibodies and their sdAb fragments indexed in the Web of Science (R) database since 1993 has been carried out. Attention has predominantly been paid to papers published from 2010 to June 2012. Key publications are presented in tables and are characterised by descriptive words, abstracts and references. The presented publications have been sorted according to seven basic criteria: review articles and monographs, heavy-chain antibodies of camelids and sharks, production of sdAb fragments using recombinant technology, characteristic properties of sdAb fragments, application of sdAb fragments in therapy, application of sdAb fragments in diagnostic and imrnunoanalytical methods and other prospective uses of sdAb fragments. This review article should highlight the typical properties of heavy-chain antibodies and sdAb fragments which differentiate them from conventional antibodies and other available recombinant fragments, and also emphasize their extremely broad application potential, mainly in human disease therapy. At the same time it allows an easy and rapid orientation in numerous publications written on this subject, and facilitates the search for the required data. Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents. Due to their unique characteristics, such as low molecular weight, high physical-chemical stability, good water solubility, and the ability to bind antigens inaccessible to conventional antibodies, they could potentially act as a substitute for conventional therapeutic drugs in the treatment of serious human diseases, and, moreover, could be broadly used in analyses and diagnostics. In this review article, an analysis of 826 publications oriented to heavy-chain antibodies and their sdAb fragments indexed in the Web of Science (R) database since 1993 has been carried out. Attention has predominantly been paid to papers published from 2010 to June 2012. Key publications are presented in tables and are characterised by descriptive words, abstracts and references. The presented publications have been sorted according to seven basic criteria: review articles and monographs, heavy-chain antibodies of camelids and sharks, production of sdAb fragments using recombinant technology, characteristic properties of sdAb fragments, application of sdAb fragments in therapy, application of sdAb fragments in diagnostic and imrnunoanalytical methods and other prospective uses of sdAb fragments. This review article should highlight the typical properties of heavy-chain antibodies and sdAb fragments which differentiate them from conventional antibodies and other available recombinant fragments, and also emphasize their extremely broad application potential, mainly in human disease therapy. At the same time it allows an easy and rapid orientation in numerous publications written on this subject, and facilitates the search for the required data.
dcterms:title
Single-domain antibody fragments derived from heavy-chain antibodies: a review Single-domain antibody fragments derived from heavy-chain antibodies: a review
skos:prefLabel
Single-domain antibody fragments derived from heavy-chain antibodies: a review Single-domain antibody fragments derived from heavy-chain antibodies: a review
skos:notation
RIV/00027162:_____/12:#0000931!RIV13-MZE-00027162
n10:predkladatel
n18:ico%3A00027162
n4:aktivita
n13:P n13:Z
n4:aktivity
P(ED0006/01/01), Z(MZE0002716202)
n4:cisloPeriodika
9
n4:dodaniDat
n8:2013
n4:domaciTvurceVysledku
n12:6105297 n12:3431525
n4:druhVysledku
n11:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
168136
n4:idVysledku
RIV/00027162:_____/12:#0000931
n4:jazykVysledku
n9:eng
n4:klicovaSlova
single-domain antibody fragment; heavy-chain antibody; antigen-binding site; camelid; shark; therapy; recombinant technology
n4:klicoveSlovo
n5:shark n5:single-domain%20antibody%20fragment n5:therapy n5:heavy-chain%20antibody n5:recombinant%20technology n5:antigen-binding%20site n5:camelid
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[561859C1678C]
n4:nazevZdroje
Veterinární Medicína
n4:obor
n17:GJ
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n15:ED0006%2F01%2F01
n4:rokUplatneniVysledku
n8:2012
n4:svazekPeriodika
57
n4:tvurceVysledku
Hruška, Karel Eyer, Luděk
n4:wos
000310673200001
n4:zamer
n14:MZE0002716202
s:issn
0375-8427
s:numberOfPages
75