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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F11%3A%230000762%21RIV12-MZE-00027162
rdf:type
n3:Vysledek skos:Concept
dcterms:description
We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall. We studied the influence of chimerism on bronchial epithelium and obliterative bronchiolitis (OB) development in pigs. Immunosuppressed and unimmunosuppressed bronchial allografts were serially obtained after transplantation. Histology was assessed and the fluorescence in situ hybridization method for Y chromosomes using pig-specific DNA-label was used to detect recipient derived cells in graft epithelium and bronchial wall, and donor cell migration to recipient organs. Early appearance of recipient-derived cells in the airway epithelium appeared predictive of epithelial destruction and of obliteration of the bronchial lumen All allografts with preserved epithelium showed epithelial chimerism throughout the follow-up. Antirejection medication did not prevent, but delayed the appearance of Y chromosome positive cells in the epithelium, or bronchial wall.
dcterms:title
Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis
skos:prefLabel
Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis
skos:notation
RIV/00027162:_____/11:#0000762!RIV12-MZE-00027162
n3:predkladatel
n8:ico%3A00027162
n4:aktivita
n12:Z
n4:aktivity
Z(MZE0002716202)
n4:cisloPeriodika
56
n4:dodaniDat
n5:2012
n4:domaciTvurceVysledku
n9:8164703 n9:3191907
n4:druhVysledku
n16:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
204829
n4:idVysledku
RIV/00027162:_____/11:#0000762
n4:jazykVysledku
n10:eng
n4:klicovaSlova
CELL TRANSPLANTATION; AIRWAY DISEASE; CONDITIONING REGIMEN; TOLERANCE; EPITHELIUM; ALLOGRAFTS; REJECTION; MICRODISSECTION; INDUCTION; INJURY
n4:klicoveSlovo
n6:ALLOGRAFTS n6:CELL%20TRANSPLANTATION n6:TOLERANCE n6:CONDITIONING%20REGIMEN n6:EPITHELIUM n6:MICRODISSECTION n6:INDUCTION n6:INJURY n6:REJECTION n6:AIRWAY%20DISEASE
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[34698E8DADE0]
n4:nazevZdroje
Respiratory Research
n4:obor
n17:FJ
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n5:2011
n4:svazekPeriodika
12
n4:tvurceVysledku
Musilová, Petra Maasilta, P., K. Aittomäki, K. Salminen, Ulla-Stina Raivio, P. M. Alho, H. S. Rubeš, Jiří Päiväniemi, Outi, E.
n4:wos
000291448500001
n4:zamer
n13:MZE0002716202
s:issn
1465-9921
s:numberOfPages
7