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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F11%3A%230000744%21RIV12-MZE-00027162
rdf:type
n9:Vysledek skos:Concept
dcterms:description
We analysed porcine antigen-specific immunity six months after experimental infection with Mycobacterium avium subsp. avium (MAA) by measuring IFN-gamma production (ELISA, qRT-PCR and flow cytometry) and lymphocyte transformation test after in vitro re-stimulation with the MAA-derived antigen. In MAA-infected animals, IFN-gamma was increased at both mRNA and protein levels in response to the specific MAA antigen in the blood, spleen and mesenteric lymph nodes. Similarly, a positive antigen-driven response was detected by proliferation assay. Using flow cytometry, we found double-positive CD4+CD8+ lymphocytes as the major T lymphocyte subset producing IFN-gamma after specific re-stimulation. In conclusion, antigen-specific immune response in swine is retained for at least six months after infection with MAA. Furthermore, we identified the presence of antigen-specific double-positive CD4+CD8+ cells in MAA-infected pigs. We analysed porcine antigen-specific immunity six months after experimental infection with Mycobacterium avium subsp. avium (MAA) by measuring IFN-gamma production (ELISA, qRT-PCR and flow cytometry) and lymphocyte transformation test after in vitro re-stimulation with the MAA-derived antigen. In MAA-infected animals, IFN-gamma was increased at both mRNA and protein levels in response to the specific MAA antigen in the blood, spleen and mesenteric lymph nodes. Similarly, a positive antigen-driven response was detected by proliferation assay. Using flow cytometry, we found double-positive CD4+CD8+ lymphocytes as the major T lymphocyte subset producing IFN-gamma after specific re-stimulation. In conclusion, antigen-specific immune response in swine is retained for at least six months after infection with MAA. Furthermore, we identified the presence of antigen-specific double-positive CD4+CD8+ cells in MAA-infected pigs.
dcterms:title
Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium
skos:prefLabel
Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium Cell-mediated immune response in swine infected with Mycobacterium avium subsp. avium
skos:notation
RIV/00027162:_____/11:#0000744!RIV12-MZE-00027162
n9:predkladatel
n13:ico%3A00027162
n3:aktivita
n8:P n8:Z
n3:aktivity
P(1B53009), P(ED0006/01/01), Z(MZE0002716202)
n3:cisloPeriodika
1-2
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n5:6439802 n5:7331614 n5:7362366 n5:7872275 n5:2415682 Kaevska, Marija n5:7153643
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
189382
n3:idVysledku
RIV/00027162:_____/11:#0000744
n3:jazykVysledku
n12:eng
n3:klicovaSlova
pig; avian tuberculosis; interferon-gamma; CD4+CD8+ T cell
n3:klicoveSlovo
n7:CD4%2BCD8%2B%20T%20cell n7:interferon-gamma n7:avian%20tuberculosis n7:pig
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[EBE78E0575D1]
n3:nazevZdroje
Veterinary Immunology and Immunopathology
n3:obor
n15:GJ
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n11:ED0006%2F01%2F01 n11:1B53009
n3:rokUplatneniVysledku
n10:2011
n3:svazekPeriodika
142
n3:tvurceVysledku
Kaevska, Marija Štromerová, Nikola Štěpánová, Hana Pavlík, Ivo Matiašovic, Ján Faldyna, Martin Pavlová, Barbora
n3:wos
000292486400013
n3:zamer
n4:MZE0002716202
s:issn
0165-2427
s:numberOfPages
6