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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F10%3A%230000705%21RIV11-MZE-00027162
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes. The facultative intracellular bacterium Francisella tularensis is the causal agent of the serious infectious disease tularemia. Despite intensive research, the pathogenetic mechanisms remain largely unknown. Generally, secreted proteins play an important role in pathogenicity of intracellular microbes. We investigated the protein composition of the culture filtrate proteins of highly virulent F. tularensis subsp. tularensis, strain SCHU S4 and attenuated F. tularensis subsp. holarctica, live vaccine strain using a comparative proteomic analysis. The majority of identified proteins have been implicated in virulence mechanisms of other pathogens, and several have been categorized as having moonlighting properties. Acid phosphatase (precursor) A (AcpA), beta-lactamase, and hypothetical protein FTT0484 were unique for the SCHU S4 strain. AcpA may be of importance for F. tularensis subsp. tularensis virulence due to the recently described AcpA role in the F. tularensis escape from phagosomes.
dcterms:title
Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains
skos:prefLabel
Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains
skos:notation
RIV/00027162:_____/10:#0000705!RIV11-MZE-00027162
n3:aktivita
n8:V n8:Z n8:P n8:I
n3:aktivity
I, P(ME08105), V, Z(MO0FVZ0000501), Z(MO0FVZ0000604)
n3:cisloPeriodika
24
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n9:2250780
n3:druhVysledku
n12:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
251331
n3:idVysledku
RIV/00027162:_____/10:#0000705
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Culture filtrate proteins; Francisella tularensis; Microbiology; Moonlighting proteins; Secreted proteins; Virulence factors
n3:klicoveSlovo
n7:Secreted%20proteins n7:Microbiology n7:Culture%20filtrate%20proteins n7:Moonlighting%20proteins n7:Francisella%20tularensis n7:Virulence%20factors
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[AF15A9AEF359]
n3:nazevZdroje
Proteomics
n3:obor
n17:EE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:projekt
n14:ME08105
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
10
n3:tvurceVysledku
Alefantis, T. Konečná, K. Klimentova, J. Lenco, J. DelVecchio, V. G. Reichelová, Markéta Stulík, J. Henrychová, L. Macela, A.
n3:wos
000285882200015
n3:zamer
n13:MO0FVZ0000604 n13:MO0FVZ0000501
s:issn
1615-9853
s:numberOfPages
12