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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F10%3A%230000657%21RIV11-AV0-00027162
rdf:type
n12:Vysledek skos:Concept
dcterms:description
In this study, we develop the HPLC assay for the direct determination of alpha-tocopheryl succinate (TOS) entrapped in the liposomes as well as monitoring of TOS chemical stability in the liposomal lyophilisates during 6-month storage period. The composition of mobile phase was optimised for separation of TOS, alpha-tocopherol (TOH) as TOS degradation product and alpha-tocopheryl acetate as internal standard. The quantification of TOS in liposomal formulation and liposomal sediment enables to calculate entrappment efficiency of TOS (EETOS). For the liposomal lyophilisates stored during 6 months, the obtained values of EETOS were higher than 90%. The chemical stability of liposomal entrapped TOS was investigated by monitoring the level of TOH. Generally, the content of liposomal TOH did not exceed 5% of the liposomal TOS content. In this study, we develop the HPLC assay for the direct determination of alpha-tocopheryl succinate (TOS) entrapped in the liposomes as well as monitoring of TOS chemical stability in the liposomal lyophilisates during 6-month storage period. The composition of mobile phase was optimised for separation of TOS, alpha-tocopherol (TOH) as TOS degradation product and alpha-tocopheryl acetate as internal standard. The quantification of TOS in liposomal formulation and liposomal sediment enables to calculate entrappment efficiency of TOS (EETOS). For the liposomal lyophilisates stored during 6 months, the obtained values of EETOS were higher than 90%. The chemical stability of liposomal entrapped TOS was investigated by monitoring the level of TOH. Generally, the content of liposomal TOH did not exceed 5% of the liposomal TOS content.
dcterms:title
Direct high-performance liquid chromatography analysis of lyophilised liposomal entrapped alpha-tocopheryl succinate Direct high-performance liquid chromatography analysis of lyophilised liposomal entrapped alpha-tocopheryl succinate
skos:prefLabel
Direct high-performance liquid chromatography analysis of lyophilised liposomal entrapped alpha-tocopheryl succinate Direct high-performance liquid chromatography analysis of lyophilised liposomal entrapped alpha-tocopheryl succinate
skos:notation
RIV/00027162:_____/10:#0000657!RIV11-AV0-00027162
n3:aktivita
n4:P n4:Z
n3:aktivity
P(KAN200520703), Z(MZE0002716202)
n3:cisloPeriodika
Supll. 16
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n9:1858955 n9:5467489 n9:9358226 n9:7911939
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
254540
n3:idVysledku
RIV/00027162:_____/10:#0000657
n3:jazykVysledku
n15:eng
n3:klicovaSlova
alpha-tocopheryl succinate; liposomes; stability; lyophilisation; high-performance liquid chromatography
n3:klicoveSlovo
n5:liposomes n5:stability n5:high-performance%20liquid%20chromatography n5:lyophilisation n5:alpha-tocopheryl%20succinate
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6A8B848E3564]
n3:nazevZdroje
Chemické listy
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n13:KAN200520703
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
104
n3:tvurceVysledku
Neužil, J. Koudelka, Štěpán Mašek, Josef Turánek-Knötigová, Pavlína Turánek, Jaroslav
n3:zamer
n6:MZE0002716202
s:issn
0009-2770
s:numberOfPages
3