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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F09%3A%230000540%21RIV10-MZE-00027162
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1 alpha and the partner factor ARNT (AhR nuclear translocator). We have previously observed that HIF-1 alpha competes with the AhR for interaction with ARNT under conditions when both factors are activated. We have therefore investigated whether TCDD-induced activation of the AhR pathway might interfere with CA IX expression. The results from the present study suggest that TCDD treatment reduces hypoxic induction of both CA IX mRNA and protein expression. Moreover, the transcriptional activity of the CA9 promoter was significantly reduced by expression of CAAhR (Constitutively active AhR), which activates, transcription in a ligand-independent manner. Finally, we found that ARNT is critical for both hypoxic induction and the TCDD-mediated inhibition of CA9 expression. Tumour-associated expression of CA IX (carbonic anhydrase IX) is to a major extent regulated by HIF-1 (hypoxia-inducible factor-1) which is important for transcriptional activation and consists of the oxygen-regulated subunit HIF-1 alpha and the partner factor ARNT (AhR nuclear translocator). We have previously observed that HIF-1 alpha competes with the AhR for interaction with ARNT under conditions when both factors are activated. We have therefore investigated whether TCDD-induced activation of the AhR pathway might interfere with CA IX expression. The results from the present study suggest that TCDD treatment reduces hypoxic induction of both CA IX mRNA and protein expression. Moreover, the transcriptional activity of the CA9 promoter was significantly reduced by expression of CAAhR (Constitutively active AhR), which activates, transcription in a ligand-independent manner. Finally, we found that ARNT is critical for both hypoxic induction and the TCDD-mediated inhibition of CA9 expression.
dcterms:title
Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX
skos:prefLabel
Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX
skos:notation
RIV/00027162:_____/09:#0000540!RIV10-MZE-00027162
n3:aktivita
n14:Z
n3:aktivity
Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716201)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n6:8362122 n6:5686350 n6:2301229
n3:druhVysledku
n11:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
339690
n3:idVysledku
RIV/00027162:_____/09:#0000540
n3:jazykVysledku
n7:eng
n3:klicovaSlova
ARNT TRANSCRIPTION FACTOR; INDUCIBLE FACTOR-I; DIOXIN RECEPTOR; SIGNALING PATHWAYS; GENE-EXPRESSION; AH RECEPTOR; PAS DOMAIN; CROSS-TALK; IDENTIFICATION; PROTEIN
n3:klicoveSlovo
n4:DIOXIN%20RECEPTOR n4:PROTEIN n4:IDENTIFICATION n4:GENE-EXPRESSION n4:AH%20RECEPTOR n4:ARNT%20TRANSCRIPTION%20FACTOR n4:SIGNALING%20PATHWAYS n4:INDUCIBLE%20FACTOR-I n4:PAS%20DOMAIN n4:CROSS-TALK
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DC237072E4E7]
n3:nazevZdroje
Biochemical Journal
n3:obor
n8:CE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
419
n3:tvurceVysledku
Vondráček, Jan Poellinger, L. Pastorek, J. Pastoreková, S. Pěnčíková, Kateřina Machala, Miroslav Gradin, K. Takáčová, M. Kopáček, J. Holotnakova, T.
n3:wos
000265196900018
n3:zamer
n12:MZE0002716201 n12:AV0Z50040702 n12:AV0Z50040507
s:issn
0264-6021
s:numberOfPages
7