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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F09%3A%230000506%21RIV10-AV0-00027162
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Damage to the genetic component of sperm seems to play the main role in the majority of cases where current approaches fail to reveal the specific cause of male infertility. In the present study, we compared semen quality in men assigned to two defined groups: men from couples with unexplained infertility - idiopathic infertility (A) and young men with no experiences of infertility (B). All samples were examined by standard ejaculate analysis and Sperm chromatin Structure Assay (SCSA). Sperm chromatin damage was significantly higher in men from group A in comparison with men from group B. Similar results were obtained by comparison of men from group A (all men were normozoospermic) and normozoospermic men from groups B. According to these results, we can suppose that chromatin disorders may be the causal factor of subfertility or infertility in some of these men. SCSA is a method which facilitates the identification of infertile men who otherwise show normal semen variables. Damage to the genetic component of sperm seems to play the main role in the majority of cases where current approaches fail to reveal the specific cause of male infertility. In the present study, we compared semen quality in men assigned to two defined groups: men from couples with unexplained infertility - idiopathic infertility (A) and young men with no experiences of infertility (B). All samples were examined by standard ejaculate analysis and Sperm chromatin Structure Assay (SCSA). Sperm chromatin damage was significantly higher in men from group A in comparison with men from group B. Similar results were obtained by comparison of men from group A (all men were normozoospermic) and normozoospermic men from groups B. According to these results, we can suppose that chromatin disorders may be the causal factor of subfertility or infertility in some of these men. SCSA is a method which facilitates the identification of infertile men who otherwise show normal semen variables.
dcterms:title
Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples
skos:prefLabel
Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples Sperm chromatin integrity in young men with no experiences of infertility and men from idiopathic infertility couples
skos:notation
RIV/00027162:_____/09:#0000506!RIV10-AV0-00027162
n4:aktivita
n16:P
n4:aktivity
P(1QS500390506)
n4:cisloPeriodika
3
n4:dodaniDat
n15:2010
n4:domaciTvurceVysledku
n6:6821413 n6:9741771 n6:2911574 n6:6098525 n6:8164703 n6:7029217 n6:9211152
n4:druhVysledku
n17:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
342936
n4:idVysledku
RIV/00027162:_____/09:#0000506
n4:jazykVysledku
n5:eng
n4:klicovaSlova
DNA fragmentation; infertility; semen quality; smoking; sperm chromatin structure assay
n4:klicoveSlovo
n10:infertility n10:sperm%20chromatin%20structure%20assay n10:smoking n10:semen%20quality n10:DNA%20fragmentation
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[BCB2DBEEAD47]
n4:nazevZdroje
Andrologia
n4:obor
n9:EB
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
8
n4:projekt
n12:1QS500390506
n4:rokUplatneniVysledku
n15:2009
n4:svazekPeriodika
41
n4:tvurceVysledku
Kopecká, Věra Rybář, Roman Marková, P. Rubeš, Jiří Kunetková, Monika Faldíková, Ludmila Zajícová, Atanáska Věžník, Zdeněk
n4:wos
000265480700002
s:issn
0303-4569
s:numberOfPages
10