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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F09%3A%230000486%21RIV10-MZE-00027162
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus. The objective of this study was to investigate the effects of postnatal exposure to benz(a)anthracene (B(a)A) and benzo(k)fluoranthene (B(k)F) on the development of the rat uterus. Neonates were injected subcutaneously on each postnatal day 1-14 with B(a)A (0.1, 1.0 or 10.0 mg/kg), B(k)F (0.1, 1.0 or 5.0 mg/kg), ethynylestradiol (EE; 1.0 ug/kg) or a vehicle. The rats were killed on day 23. All doses of B(a)A and B(k)F induced a significant reduction of the uterine weight, a reduction of the estrogen receptor alpha expression in the luminal epithelium, glandular epithelium and stromal cells. Moreover, the uterotrophic response to EE (three-day administration of 1.0 ug/kg on postnatal days 20-22) in rats exposed to B(a)A, B(k)F and EE was significantly lower than in controls. The study showed that postnatal exposure to B(a)A or B(k)F results in morphological and functional disorders of the immature rat uterus.
dcterms:title
Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene
skos:prefLabel
Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene Morphological and functional disorders of the immature rat uterus after postnatal exposure to benz(a)anthracene and benzo(k)fluoranthene
skos:notation
RIV/00027162:_____/09:#0000486!RIV10-MZE-00027162
n3:aktivita
n7:Z n7:P
n3:aktivity
P(GA525/05/2695), Z(MZE0002716201)
n3:cisloPeriodika
3
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n9:7153643 n9:7988370 n9:3923673 n9:7362366
n3:druhVysledku
n14:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
327471
n3:idVysledku
RIV/00027162:_____/09:#0000486
n3:jazykVysledku
n18:eng
n3:klicovaSlova
polcyclic aromatic hydrocarbons; estrogen receptor; immunohistochemistry; rat uterotrophic bioassay
n3:klicoveSlovo
n11:immunohistochemistry n11:polcyclic%20aromatic%20hydrocarbons n11:estrogen%20receptor n11:rat%20uterotrophic%20bioassay
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[3973EFF02004]
n3:nazevZdroje
Environmental Toxicology and Pharmacology
n3:obor
n4:GJ
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n8:GA525%2F05%2F2695
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
27
n3:tvurceVysledku
Matiašovic, Ján Mašková, Jarmila Kummer, Vladimír Faldyna, Martin
n3:wos
000264387200014
n3:zamer
n16:MZE0002716201
s:issn
1382-6689
s:numberOfPages
6