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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F08%3A%230000454%21RIV09-MZE-00027162
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Monomethylated benz[a]anthracenes (MeBaAs) are an important group of methylated derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution reportedly affects their mutagenicity and tumor-initiating activity, little is known about the impact of methylation on the effects associated with activation of the aryl hydrocarbon receptor (AhR)-dependent gene expression and/or toxic events associated with tumor promotion. In the present study, we studied the effects of a series of MeBaAs on the above-mentioned end points in rat liver cell lines and compared them with the effects of benz[a]anthracene (BaA) and the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Methyl substitution enhanced the AhR-mediated activity of BaA derivatives and cell proliferation in contact-inhibited WB-F344 cells. 1-, 2-, 8-, 10-, 11-, and 12-MeBaA inhibited gap junctional intercellular communication (GJIC) in WB-F344 cells. MeBaAs induced low DNA adduct formation. Monomethylated benz[a]anthracenes (MeBaAs) are an important group of methylated derivatives of polycyclic aromatic hydrocarbons (PAHs). Although the methyl substitution reportedly affects their mutagenicity and tumor-initiating activity, little is known about the impact of methylation on the effects associated with activation of the aryl hydrocarbon receptor (AhR)-dependent gene expression and/or toxic events associated with tumor promotion. In the present study, we studied the effects of a series of MeBaAs on the above-mentioned end points in rat liver cell lines and compared them with the effects of benz[a]anthracene (BaA) and the potent carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Methyl substitution enhanced the AhR-mediated activity of BaA derivatives and cell proliferation in contact-inhibited WB-F344 cells. 1-, 2-, 8-, 10-, 11-, and 12-MeBaA inhibited gap junctional intercellular communication (GJIC) in WB-F344 cells. MeBaAs induced low DNA adduct formation. Monometylované benz[a]antraceny (MeBaA) jsou důležitou skupinou mezi metylovanými polycyklickými aromatickými uhlovodíky. Přestože vliv metylace na mutagenitu a tumorovou iniciaci je znám, my jsme v této studii na krysích potkaních buňkách sledovali, jak metylace ovlivňuje efekty spojené s aktivací aryl-hadrokarbonového receptoru (AhR), jako změny genové exprese a/nebo děje související s tumorovou promocí ve srovnání s benz[a]antracenem (BaA) a známým silným karcinogenm 7,12-dimethylbenz[a]antracenem (DMBA). Naše výsledky ukazují, že metylace zesiluje AhR-dependentní účinky BaA derivátů a zvyšuje buněčnou proliferaci v kontaktně inhibovaných buňkách.1-,2-,8-,10-,11- a 12-MeBeA inhibovali mezibuněčnou komunikaci mezerovými spoji. Všechny MeBaA navozovali malou tvorbu DNA aduktů.
dcterms:title
Toxic effects of methylated benz[a]anthracenes in liver cells Toxické efekty metylovaných benz[a]antracenů v jaterních buňkách Toxic effects of methylated benz[a]anthracenes in liver cells
skos:prefLabel
Toxické efekty metylovaných benz[a]antracenů v jaterních buňkách Toxic effects of methylated benz[a]anthracenes in liver cells Toxic effects of methylated benz[a]anthracenes in liver cells
skos:notation
RIV/00027162:_____/08:#0000454!RIV09-MZE-00027162
n3:aktivita
n10:Z
n3:aktivity
Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390703), Z(MZE0002716201)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2009
n3:domaciTvurceVysledku
n7:9008004 n7:8362122 n7:5686350 n7:6556124 n7:2301229 n7:4628713
n3:druhVysledku
n5:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
400294
n3:idVysledku
RIV/00027162:_____/08:#0000454
n3:jazykVysledku
n17:eng
n3:klicovaSlova
JUNCTIONAL INTERCELLULAR COMMUNICATION; STEM-LIKE CELLS; EPITHELIAL-CELLS; METABOLIC-ACTIVATION; DNA-ADDUCTS; CARCINOGENIC POTENCY; NONGENOTOXIC EVENTS; WB-F344 CELLS; AH RECEPTOR
n3:klicoveSlovo
n4:STEM-LIKE%20CELLS n4:AH%20RECEPTOR n4:DNA-ADDUCTS n4:NONGENOTOXIC%20EVENTS n4:METABOLIC-ACTIVATION n4:EPITHELIAL-CELLS n4:JUNCTIONAL%20INTERCELLULAR%20COMMUNICATION n4:WB-F344%20CELLS n4:CARCINOGENIC%20POTENCY
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[1DBF7F3E46E7]
n3:nazevZdroje
Chemical Research in Toxicology
n3:obor
n12:DN
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n14:2008
n3:svazekPeriodika
21
n3:tvurceVysledku
Vondráček, Jan Marvanová, Soňa Topinka, J. Trilecová, Lenka Milcová, A. Machala, Miroslav Nováková, Z. Pěnčíková, Kateřina Krčmář, Pavel
n3:wos
000253278700026
n3:zamer
n11:MZE0002716201 n11:AV0Z50390703 n11:AV0Z50040702 n11:AV0Z50040507
s:issn
0893-228X
s:numberOfPages
10