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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F08%3A%230000359%21RIV09-MZE-00027162
rdf:type
skos:Concept n16:Vysledek
dcterms:description
The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver. Cíl studie: prošetřit potenciální estrogenní/antiestrogenní účinky benzo(a)pyrenu (BaP), benz(a)antracenu (BaA), fluorantenu (Fla) and benzo(k)fluorantenu (BkF) použitím uterotrofní bioassay u immaturních potkanů. Výsledky nasvědčují tomu, že při aplikaci 10 mg/kg/den vykazovaly BaA, BaP a Fla slabou estrogenní aktivitu, což potvrdil signifikantní nárůst váhy dělohy a hypertrofie luminálního epitelu. Tento efekt byl zprostředkován via ER alfa a byl blokován simultánní aplikací ER antagonisty ICI 182,780. Aplikace těchto PAHs vedla ke snížení exprese ER v děloze. BaA indukoval průkazný estrogenní účinek již od dávky 0.1 mg/kg. Antiestrogenita BkF, patřícího mezi AhR agonisty nebyla potvrzena. Studované PAHs nevyvolaly v děložní tkáni zřejmé genotoxické poškození, o čemž svědčila slabá úroveň barvení Ser-15-fosforylace protein p53. S výjimkou Fla všechny zbývající PAHs zvyšovaly CYP1-dependentní aktivitu monooxygenace v játrech. The study: estrogenic/antiestrogenic effects of benzo(a)pyrene (BaP), benz(a)anthracene (BaA), fluoranthene (Fla) and benzo(k)fluoranthene (BkF), using the immature rat uterotrophic assay. The results suggest that BaA, BaP and Fla behaved as estrogen-like compounds, when applied at 10 mg/kg/day, as documented by a significant increase of uterine weight and hypertrophy of luminal epithelium. These effects were likely to be mediated by ER alpha, which was downregulated following the treatment with PAHs, as they were inhibited by treatment with ER antagonist ICI 182,780. BaA induced a significant estrogenic effect already at the dose of 0.1 mg/kg/day. The proposed antiestrogenicity of the potent AhR agonist BkF was not confirmed. The PAHs under study did not induce marked genotoxic damage in uterine tissues, as documented by the lack of Ser-15-phoshorylated p53 protein staining. With the exception of Fla, all three remaining PAHs increased CYP1-dependent monooxygenation activities in liver.
dcterms:title
Estrogenní aktivita polycyklických aromatických uhlovodíků v děloze immaturních Wistar potkanů Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats
skos:prefLabel
Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats Estrogenic activity of environmental polycyclic aromatic hydrocarbons in uterus of immature Wistar rats Estrogenní aktivita polycyklických aromatických uhlovodíků v děloze immaturních Wistar potkanů
skos:notation
RIV/00027162:_____/08:#0000359!RIV09-MZE-00027162
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA525/05/2695), Z(AV0Z50040507), Z(AV0Z50040702), Z(MZE0002716201)
n3:cisloPeriodika
3
n3:dodaniDat
n7:2009
n3:domaciTvurceVysledku
n5:5752205 n5:3923673 n5:7988370 n5:2563177 n5:5686350 n5:7369727 n5:2301229
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
366569
n3:idVysledku
RIV/00027162:_____/08:#0000359
n3:jazykVysledku
n9:eng
n3:klicovaSlova
polycyclic aromatic hydrocarbons; rat immature uterotrophic assay; estrogen receptor; cytochrome P450; estradiol metabolism; p53
n3:klicoveSlovo
n4:p53 n4:estrogen%20receptor n4:polycyclic%20aromatic%20hydrocarbons n4:rat%20immature%20uterotrophic%20assay n4:cytochrome%20P450 n4:estradiol%20metabolism
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[EF4B0F551410]
n3:nazevZdroje
Toxicology Letters
n3:obor
n15:GJ
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n18:GA525%2F05%2F2695
n3:rokUplatneniVysledku
n7:2008
n3:svazekPeriodika
180
n3:tvurceVysledku
Mašková, Jarmila Polášková, Pavlína Machala, Miroslav Zralý, Zdeněk Kummer, Vladimír Vondráček, Jan Neča, Jiří
n3:wos
000259461000008
n3:zamer
n6:MZE0002716201 n6:AV0Z50040507 n6:AV0Z50040702
s:issn
0378-4274
s:numberOfPages
10