This HTML5 document contains 49 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n13http://linked.opendata.cz/resource/domain/vavai/projekt/
n7http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n14http://linked.opendata.cz/ontology/domain/vavai/
n8http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00027162%3A_____%2F08%3A%230000344%21RIV09-MZE-00027162/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n10http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n6http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n16http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F08%3A%230000344%21RIV09-MZE-00027162
rdf:type
n14:Vysledek skos:Concept
dcterms:description
The aim of this study was to characterize a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution and changes in proliferative capacity of lymphocytes 1, 3 and 7 days after the administration of 2 mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In blood, neutrophilia and lymphopenia without leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly. In the thymus, DXP led to a marked reduction of numbers of CD4+CD8+ thymocytes. The proliferative capacity of lymphocytes was lower in the blood and spleen only on day 1, no changes were detected in lymph nodes or in bone marrow. The results demonstrate that this DXP application protocol is useful for the experimental induction of short-lasting immunosuppression in rabbits. Cílem studie bylo charakterizovat model imunosuprese u králíka na základě změn v distribuci subpopulací lymfocytů a změn v jejich proliferační kapacitě 1, 3 a 7 dní po aplikaci 2 mg/kg dexamethazon-fosfátu (DXP) třikrát v 6-hodinových intervalech. V krvi byla detekována neutrofilie a lymfopenie bez leukocytózy. Jeden den po aplikaci DXP, všechny subpopulace lymfocytů klesly v krvi, zatímco v kostní dřeni se absolutní počet všech lymfocytárních subpopulací signifikantně zvýšil, kromě CD79alfa+ buněk, jejichž počet stoupl pouze relativně. Efekt DXP na lymfocyty ze sleziny a mezenteriální a popliteální mízní uzlinu nebyl tak výrazný. V thymu, DXP vyvolal výraznou redukci relativního i absolutního počtu CD4+CD8+ thymocytů. Proliferační kapacita lymfocytů byla nižší pouze první den v krvi a slezině, žádné změny nebyly detekovány v mízních uzlinách a kostní dřeni. Výsledky ukazují, že takovýto protokol aplikace DXP je použitelný pro experimentální indukci krátkodobé imunosuprese u králíka. The aim of this study was to characterize a model of immunosuppression in rabbits, based on changes in the lymphocyte subset distribution and changes in proliferative capacity of lymphocytes 1, 3 and 7 days after the administration of 2 mg/kg dexamethasone phosphate (DXP) three times at 6-h intervals. In blood, neutrophilia and lymphopenia without leukocytosis was detected. One day after DXP administration the absolute numbers of all lymphocyte subsets decreased in the blood, whereas in bone marrow, absolute numbers of all lymphocyte subsets increased significantly. In the thymus, DXP led to a marked reduction of numbers of CD4+CD8+ thymocytes. The proliferative capacity of lymphocytes was lower in the blood and spleen only on day 1, no changes were detected in lymph nodes or in bone marrow. The results demonstrate that this DXP application protocol is useful for the experimental induction of short-lasting immunosuppression in rabbits.
dcterms:title
Dexamethasone-induced immunosuppression: a rabbit model Dexamethazonem indukovaná imunosuprese - králičí model Dexamethasone-induced immunosuppression: a rabbit model
skos:prefLabel
Dexamethasone-induced immunosuppression: a rabbit model Dexamethazonem indukovaná imunosuprese - králičí model Dexamethasone-induced immunosuppression: a rabbit model
skos:notation
RIV/00027162:_____/08:#0000344!RIV09-MZE-00027162
n3:aktivita
n18:Z n18:P
n3:aktivity
P(GA524/05/2714), Z(MZE0002716201)
n3:cisloPeriodika
3-4
n3:dodaniDat
n16:2009
n3:domaciTvurceVysledku
n7:6502415 n7:5137365 n7:7153643 n7:1317121
n3:druhVysledku
n4:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
363193
n3:idVysledku
RIV/00027162:_____/08:#0000344
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Glucocorticoid; Lymphocyte subsets; Lagomorphs; Flow cytometry
n3:klicoveSlovo
n10:Flow%20cytometry n10:Lymphocyte%20subsets n10:Glucocorticoid n10:Lagomorphs
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[175E7546002A]
n3:nazevZdroje
Veterinary Immunology and Immunopathology
n3:obor
n9:GJ
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n13:GA524%2F05%2F2714
n3:rokUplatneniVysledku
n16:2008
n3:svazekPeriodika
122
n3:tvurceVysledku
Levá, Lenka Jeklová, Edita Faldyna, Martin Jaglič, Zoran
n3:wos
000255325600004
n3:zamer
n8:MZE0002716201
s:issn
0165-2427
s:numberOfPages
10