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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F08%3A%230000340%21RIV09-MZE-00027162
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Piglets after weaning were challenged by Shiga toxigenic E. coli strain (STEC). Piglets of experimental group were intramuscularly treated with colistin. After the challenge, colonisation of the intestines was observed in both group of piglets. STEC were detected in the mesenteric lymph nodes of untreated piglets. In colistin treated group of piglets (11 piglets) oedema disease developed in 10 piglets, eigt of which died or were euthanized ante finem. In the untreated group (11 piglets) oedema disease developed in five piglets, four of which died or were euthanized. We there propose, that the STEC lysed by colistin suddenly released the shiga toxin from bacterial cells immediately after their passage through the intestinal wall. That could explain a more severe course of oedema disease in the treated piglets. Even though high amounts of STEC were presented in the lymph nodes of untreted piglets, the toxin was not released abruptly because the bacterial cells were not damaged. Selata po odstavu byla infikována shigatoxigenním kmenem E. coli (STEC). Selatům pokusné skupiny byl po dobu pokusu intramuskulárně aplikován kolistin. U obou skupin bylo pozorováno osídlení střeva STEC. STEC byly detekovány v mízních uzlinách selat neošetřených kolistinem. Ve skupině ošetřených kolistinem (11 selat) došlo k onemocnění edémovou nemocí u 10 selat a 8 z nich uhynulo nebo bylo utraceno ante finem. V kontrolní skupině (11 selat) onemocnělo edémovou nemocí 5 selat a 4 z nich uhynula nebo byla utracena ante finem. Předpokládáme, že kolistin destrukcí bakteriální stěny vyvolal náhlé uvolnění shiga toxinu z buněk STEC pronikající přes stěnu střeva. To může vysvětlovat těžší průběh edémové nemoci u selat ošetřených kolistinem. U selat neošetřených kolistinem, i když byly STEC ve vysokých počtech detekovány v mezenteriálních mízních uzlinách, nebyl toxin uvolněn tak náhle, protože stěny bakteriálních buněk nebyly poškozeny. Piglets after weaning were challenged by Shiga toxigenic E. coli strain (STEC). Piglets of experimental group were intramuscularly treated with colistin. After the challenge, colonisation of the intestines was observed in both group of piglets. STEC were detected in the mesenteric lymph nodes of untreated piglets. In colistin treated group of piglets (11 piglets) oedema disease developed in 10 piglets, eigt of which died or were euthanized ante finem. In the untreated group (11 piglets) oedema disease developed in five piglets, four of which died or were euthanized. We there propose, that the STEC lysed by colistin suddenly released the shiga toxin from bacterial cells immediately after their passage through the intestinal wall. That could explain a more severe course of oedema disease in the treated piglets. Even though high amounts of STEC were presented in the lymph nodes of untreted piglets, the toxin was not released abruptly because the bacterial cells were not damaged.
dcterms:title
The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets Vliv intramuskulární aplikace kolistinu na vznik a průběh experimentálně vyvolané edémové nemoci selat po odstavu The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets
skos:prefLabel
Vliv intramuskulární aplikace kolistinu na vznik a průběh experimentálně vyvolané edémové nemoci selat po odstavu The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets
skos:notation
RIV/00027162:_____/08:#0000340!RIV09-MZE-00027162
n4:aktivita
n13:Z
n4:aktivity
Z(MZE0002716201)
n4:cisloPeriodika
1-2
n4:dodaniDat
n5:2009
n4:domaciTvurceVysledku
n7:7988370 n7:4214064 n7:1109278 n7:6879101 n7:3923673 n7:6757669
n4:druhVysledku
n10:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
365126
n4:idVysledku
RIV/00027162:_____/08:#0000340
n4:jazykVysledku
n17:eng
n4:klicovaSlova
Escherichia coli; ED; STEC; colonising factors
n4:klicoveSlovo
n8:colonising%20factors n8:Escherichia%20coli n8:STEC n8:ED
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[23B0072D6D60]
n4:nazevZdroje
Veterinary Microbiology
n4:obor
n6:GJ
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n5:2008
n4:svazekPeriodika
128
n4:tvurceVysledku
Alexa, Pavel Kummer, Vladimír Mašková, Jarmila Konstantinová, Lucie Kulich, Pavel Hamřík, Jaroslav
n4:wos
000253831500016
n4:zamer
n15:MZE0002716201
s:issn
0378-1135
s:numberOfPages
6