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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F08%3A%230000333%21RIV09-MZE-00027162
rdf:type
skos:Concept n17:Vysledek
dcterms:description
To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination. Cílem studie bylo charakterizovat vliv benzo(a)pyrenu (B(a)P) na vyvíjející se imunitní systém novorozených potkanů. Zvířata byla vystavena rozdílné koncentraci (0,1; 1,0 a 10,0 mg/kg/den) B(a)P v průběhu prvních 14 dní života a utracena 23.den experimentu Laboratorními analýzami bylo zjištěno, že klesající počet erytrocytů byl v přímé korelaci s dávkou B(a)P. U exponovaných zvířat také stoupal počet T lymfocytů a jejich mitogenní aktivita. Naopak produkce cytokinů IFN-gama a IL-4 měřená na úrovni mRNA byla nižší než u neexponovaných zvířat. Pokles poměru IFN-gama/IL-4 byl závislý na dávce B(a)P. Z těchto údajů se dá usoudit na to, že expozice novorozených mláďat účinku B(a)P může modulovat imunitní odpověď na infekci a/nebo vakcinaci. To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subject animals, the overall counts of T cells in the spleen and the mitogenic activity increased. A decrease in the production of both IFN-gama and IL-4 (measured at the mRNA level) as well as the decreasing IFN-gama/IL-4 ratio in rat splenocytes were dependent on the dose of B[a]P. From this we may deduce that exposure to B[a]P in immature animals may modulate the immune response to infection and/or vaccination.
dcterms:title
Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů
skos:prefLabel
Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Effects of postnatal exposure to benzo[a]pyrene on the immunity of immature rats Vliv postnatální expozice účinku benzo[a]pyrenu na imunitu novorozených potkanů
skos:notation
RIV/00027162:_____/08:#0000333!RIV09-MZE-00027162
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GA525/05/2695), Z(MZE0002716201)
n3:cisloPeriodika
2
n3:dodaniDat
n12:2009
n3:domaciTvurceVysledku
n4:3923673 n4:7988370 n4:7362366 n4:7153643 n4:6502415
n3:druhVysledku
n6:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
365417
n3:idVysledku
RIV/00027162:_____/08:#0000333
n3:jazykVysledku
n18:eng
n3:klicovaSlova
polycyclic aromatic hydrocarbons; immunity; IFN-gama; IL-4; cytokines
n3:klicoveSlovo
n9:polycyclic%20aromatic%20hydrocarbons n9:IL-4 n9:IFN-gama n9:immunity n9:cytokines
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1714D2C21FC2]
n3:nazevZdroje
Veterinární medicína
n3:obor
n15:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:GA525%2F05%2F2695
n3:rokUplatneniVysledku
n12:2008
n3:svazekPeriodika
53
n3:tvurceVysledku
Faldyna, Martin Levá, Lenka Matiašovic, Ján Kummer, Vladimír Mašková, Jarmila
n3:wos
000253944700005
n3:zamer
n11:MZE0002716201
s:issn
0375-8427
s:numberOfPages
8