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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F07%3A%230000281%21RIV08-MZE-00027162
rdf:type
n15:Vysledek skos:Concept
dcterms:description
PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures. PAHs s molekulární hmotností 278 většinou nejsou zahrnuty v současných monitorovacích programech. Přestože benzo[g]chrysen (BgChry) a dibenzo[a,h]anthracen jsou dlouhou dobu studovány jako genotoxické, tumor-iniciační sloučeniny, je málo známo o možných tumor-promočních schopnostech této skupiny PAHs. Zabývali jsme se jejich vlivem na aktivaci receptoru AhR, indukci enzymů metabolizujících xenobiotika, narušení kontroly buněčného cyklu v konfluentní buněčné populaci a inhibici mezibuněčné populace za použití potkaních jaterních epiteliálních buněk WB-F344 jako modelu jaterních progenitorových buněk. Výsledky ukazují, že dibenzoanthraceny a benzochryseny s výjimkou BgChry pravděpodobně působí prostřednictvím deregulace buněčné proliferace v jaterních epiteliálních buňkách, což souvisí s jejich relativně vysokou aktivitou řízenou AhR. Narušení kontroly buněčného cyklu by mohlo přispívat k jejich karcinogenním účinkům, stejně jako ke karcinogenitě komplexních environmentálních směsí. PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures.
dcterms:title
Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Dibenzoanthraceny a benzochryseny projevují jak genotoxické, tak negenotoxické účinky v potkaních jaterních 'stem-like' buňkách Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells
skos:prefLabel
Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells Dibenzoanthraceny a benzochryseny projevují jak genotoxické, tak negenotoxické účinky v potkaních jaterních 'stem-like' buňkách
skos:notation
RIV/00027162:_____/07:#0000281!RIV08-MZE-00027162
n3:strany
147;159
n3:aktivita
n14:Z n14:P
n3:aktivity
P(KJB6004407), Z(AV0Z50040507), Z(AV0Z50390512), Z(MZE0002716201)
n3:cisloPeriodika
1-2
n3:dodaniDat
n16:2008
n3:domaciTvurceVysledku
n4:9008004 n4:2301229 n4:8262128 n4:5686350 n4:8362122 n4:7369727
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
417079
n3:idVysledku
RIV/00027162:_____/07:#0000281
n3:jazykVysledku
n18:eng
n3:klicovaSlova
aryl hydrocarbon receptor; genotoxicity; rat liver epithelial cells; benzochrysenes; dibenzoanthracenes; cell proliferation
n3:klicoveSlovo
n5:genotoxicity n5:cell%20proliferation n5:aryl%20hydrocarbon%20receptor n5:rat%20liver%20epithelial%20cells n5:dibenzoanthracenes n5:benzochrysenes
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[3CB0455C17F2]
n3:nazevZdroje
Toxicology
n3:obor
n8:EB
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:projekt
n9:KJB6004407
n3:rokUplatneniVysledku
n16:2007
n3:svazekPeriodika
232
n3:tvurceVysledku
Švihálková, Lenka Neča, Jiří Sevastyanová, O. Machala, Miroslav Vondráček, Jan Pěnčíková, Kateřina Marvanová, Soňa Topinka, J. Kozubík, A.
n3:zamer
n7:MZE0002716201 n7:AV0Z50040507 n7:AV0Z50390512
s:issn
0300-483X
s:numberOfPages
13