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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F06%3A%230000061%21RIV07-MZE-00027162
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Pět dní po narození životaschopné klisničky se u ní objevil žlutý vodnatý průjem bez dalších celkových příznaků. Průjem ustal čtyři dny později. Jedenáctý den života se u zvířate objevila apatie, po které následovala svalová slabost a silný vodnatý průjem. Postižené zvíře neodpovídalo na terapii. Klisnička spontánně uhynula 21. den života za příznaků střevní koliky a pneumonie. Hematologické vyšetření prokázalo nizkou koncentraci erytrocytů a neselektivní lymfopenii. Fagocytární aktivita byla lehce zvýšená, naopak lymfocytární aktivita byla inhibována. Histopatologické vyšetření prokázalo těžké poškození lymfatických orgánů. T a B lymfocyty stejně jako antigen prezentující makrofágy nebyly uspořádány v charakteristických oblastech a množství těchto buněk bylo nižší než by se dalo očekávat. Histopatologické změny v lymfatických orgánech připomínaly změny popisované v literatuře jako těžká kombinovaná imunodeficience. Five days after birth of the viable filly appeared yellow watery diarrhea without any signs of systemic disease. Four days later the diarrhea ceased. On 11th day, the animal showed apathy, and a few days later, the foal was very lethargic, suffered from muscular weakness and severe watery diarrhea that reappeared. The illness did not respond to therapy. At the age of 21 days the filly spontaneously died under symptoms of intestinal colic and pneumonia. Haematologic examinations revealed lower numbers of erythrocytes as well as not selective lymphopenia. Phagocytic activity was slightly increased, lymphocyte activity was inhibited. Histopathology showed severe alteration of the lymphatic organs. T and B lymphocytes and antigen-presenting macrophages were not arranged in characteristic areas, and quantity of these cells was lower than could be expected. Histopathologic changes in lymphatic organs of resembled those described in the literature as severe combined immunodeficiency. Five days after birth of the viable filly appeared yellow watery diarrhea without any signs of systemic disease. Four days later the diarrhea ceased. On 11th day, the animal showed apathy, and a few days later, the foal was very lethargic, suffered from muscular weakness and severe watery diarrhea that reappeared. The illness did not respond to therapy. At the age of 21 days the filly spontaneously died under symptoms of intestinal colic and pneumonia. Haematologic examinations revealed lower numbers of erythrocytes as well as not selective lymphopenia. Phagocytic activity was slightly increased, lymphocyte activity was inhibited. Histopathology showed severe alteration of the lymphatic organs. T and B lymphocytes and antigen-presenting macrophages were not arranged in characteristic areas, and quantity of these cells was lower than could be expected. Histopathologic changes in lymphatic organs of resembled those described in the literature as severe combined immunodeficiency.
dcterms:title
Severe combined immunodeficiency in a fell pony foal Severe combined immunodeficiency in a fell pony foal Těžká kombinovaná imunodeficience u hříběte Fell pony
skos:prefLabel
Těžká kombinovaná imunodeficience u hříběte Fell pony Severe combined immunodeficiency in a fell pony foal Severe combined immunodeficiency in a fell pony foal
skos:notation
RIV/00027162:_____/06:#0000061!RIV07-MZE-00027162
n3:strany
2
n3:aktivita
n12:Z
n3:aktivity
Z(MZE0002716201)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2007
n3:domaciTvurceVysledku
n16:7153643
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
499077
n3:idVysledku
RIV/00027162:_____/06:#0000061
n3:jazykVysledku
n4:eng
n3:klicovaSlova
horse, immunity, deficiency, clinical pathology, histopathology
n3:klicoveSlovo
n6:clinical%20pathology n6:immunity n6:horse n6:deficiency n6:histopathology
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[EF5D997BD0B5]
n3:nazevZdroje
Journal of Veterinary Medicine A
n3:obor
n9:GJ
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n8:2006
n3:tvurceVysledku
Faldyna, Martin
n3:zamer
n13:MZE0002716201
s:issn
0931-184X
s:numberOfPages
5