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Statements

Subject Item
n2:RIV%2F00027162%3A_____%2F01%3A80000016%21RIV%2F2002%2FMZE%2FM03002%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Study in OVX rats treated orally with silymarin for a period of 30 days (25 or 50 mg per day) demonstrated the development of histological and functional uterine alterations which were similar to those induced by oral treatment with estradiol. Findings typical of estrogenic effect included an increase in uterine weight and hypertrophy of the luminal epithelium. Significant changes in ER alpha expression in the endometrium and in concentrations of serum thyroid hormones were also observed. Study in OVX rats treated orally with silymarin for a period of 30 days (25 or 50 mg per day) demonstrated the development of histological and functional uterine alterations which were similar to those induced by oral treatment with estradiol. Findings typical of estrogenic effect included an increase in uterine weight and hypertrophy of the luminal epithelium. Significant changes in ER alpha expression in the endometrium and in concentrations of serum thyroid hormones were also observed.
dcterms:title
Estrogenic effects of silymarin in ovariectomized rats Estrogenic effects of silymarin in ovariectomized rats
skos:prefLabel
Estrogenic effects of silymarin in ovariectomized rats Estrogenic effects of silymarin in ovariectomized rats
skos:notation
RIV/00027162:_____/01:80000016!RIV/2002/MZE/M03002/N
n3:strany
17;23
n3:aktivita
n13:Z
n3:aktivity
Z(MZE-M03-99-01)
n3:cisloPeriodika
1
n3:dodaniDat
n9:2002
n3:domaciTvurceVysledku
n17:3094618
n3:druhVysledku
n4:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
679631
n3:idVysledku
RIV/00027162:_____/01:80000016
n3:jazykVysledku
n5:eng
n3:klicovaSlova
silymarin; rat; uterus; estrogenic effect; estrogen receptor; cytochrome P450; thyroid hormones
n3:klicoveSlovo
n6:thyroid%20hormones n6:estrogen%20receptor n6:estrogenic%20effect n6:rat n6:silymarin n6:cytochrome%20P450 n6:uterus
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3246B5AE3461]
n3:nazevZdroje
Veterinární Medicína
n3:obor
n12:GJ
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n9:2001
n3:svazekPeriodika
46
n3:tvurceVysledku
Kummer, Vladimír
n3:zamer
n15:MZE-M03-99-01
s:issn
0375-8427
s:numberOfPages
7