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Statements

Subject Item
n2:RIV%2F00027022%3A_____%2F13%3A00000439%21RIV14-MPO-00027022
rdf:type
skos:Concept n9:Vysledek
dcterms:description
To improve glutathione bioavailability after oral administration we have incorporated it into microparticles of ethylcellulose and/or cellulose acetate phthalate. Commercial FMC’s Aquacoat® EC (ethylcellulose) and Aquacoat® CPD (cellulose acetate phthalate) pseudo-latex preparations have been used for the microparticles production. FMC’s Aquacoat® pseudo-latex technology enables aqueous presentation of water-insoluble polymers. These reliable aqueous functional coatings are designed for use in both pharmaceutical and nutritional solid dose applications. They provide desired modified release profiles with the added benefit of global regulatory acceptance. Chitosan (medium molecular weight ) was added to the Aquacoat® pseudo-latex mixtures in amount of 5 - 10 % of DM to improve mucoadhesivity of the microparticles. Two methods of the microparticles preparation were tested and compared – conventional spray drying and the carbon dioxide assisted nebulisation. To improve glutathione bioavailability after oral administration we have incorporated it into microparticles of ethylcellulose and/or cellulose acetate phthalate. Commercial FMC’s Aquacoat® EC (ethylcellulose) and Aquacoat® CPD (cellulose acetate phthalate) pseudo-latex preparations have been used for the microparticles production. FMC’s Aquacoat® pseudo-latex technology enables aqueous presentation of water-insoluble polymers. These reliable aqueous functional coatings are designed for use in both pharmaceutical and nutritional solid dose applications. They provide desired modified release profiles with the added benefit of global regulatory acceptance. Chitosan (medium molecular weight ) was added to the Aquacoat® pseudo-latex mixtures in amount of 5 - 10 % of DM to improve mucoadhesivity of the microparticles. Two methods of the microparticles preparation were tested and compared – conventional spray drying and the carbon dioxide assisted nebulisation.
dcterms:title
New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India). New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India).
skos:prefLabel
New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India). New glutathione formulation for sustained release from gastrointestinal tract Asian Congress on Biotechnology (Poster. Asian Congress on Biotechnology 2013. December 15-19, 2013. Dilli, India).
skos:notation
RIV/00027022:_____/13:00000439!RIV14-MPO-00027022
n9:predkladatel
n10:ico%3A00027022
n3:aktivita
n13:P
n3:aktivity
P(FR-TI3/496)
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n14:3881261 n14:4765419 n14:2806762 n14:1428918 n14:1955071
n3:druhVysledku
n11:O
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
91585
n3:idVysledku
RIV/00027022:_____/13:00000439
n3:jazykVysledku
n8:eng
n3:klicovaSlova
glutathione; sustained release; Aquacoat EC; Aquacoat CPD
n3:klicoveSlovo
n7:sustained%20release n7:glutathione n7:Aquacoat%20CPD n7:Aquacoat%20EC
n3:kontrolniKodProRIV
[9174272F942E]
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n15:FR-TI3%2F496
n3:rokUplatneniVysledku
n12:2013
n3:tvurceVysledku
Šandriková, Viera Hromádka, Róbert Beran, Miloš Adámek, Lubomír Urban, Marian Drahorád, Josef Molík, Petr