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Statements

Subject Item
n2:RIV%2F00027014%3A_____%2F14%3A%230002029%21RIV15-MZE-00027014
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://www.vuzv.cz/sites/File/_privat/14074.pdf
dcterms:description
The exploitation of the genetic factors affecting the health status of farm animals represents an alternative approach to controlling the diseases caused by microbial pathogens. The determination of innate immunity based on the genotype of the germplasm cells is a constraint for specificity but becomes an advantage in breeding schemes. The structural deviations among Toll-like receptors (TLRs), as the most frequently studied innate immunity components, have been documented at all levels, i.e., interspecific, inter- and intravarietal, in the main farm species. The current computational methods facilitate the prediction of the functional consequences of the observed mutations. Subsequently, these predictions can be verified through immunological responsiveness and population-wide association studies. The frequency and haplotype grouping of individual polymorphisms are used to track the origin and selection coefficient as independent indicators of functional changes. The Toll-like receptor variants associated with mastitis and mycobacterial infection have been identified in cattle, consequently, the targeting of these proteins in breeding could contribute to disease control. The range of infections affected by TLR polymorphisms suggests that the improvement of innate resistance is feasible in more species. Thus, the traditional breeds and wild populations should be regarded as the resources of genetic variability accessible for these purposes. (C) 2013 Elsevier B.V. All rights reserved. The exploitation of the genetic factors affecting the health status of farm animals represents an alternative approach to controlling the diseases caused by microbial pathogens. The determination of innate immunity based on the genotype of the germplasm cells is a constraint for specificity but becomes an advantage in breeding schemes. The structural deviations among Toll-like receptors (TLRs), as the most frequently studied innate immunity components, have been documented at all levels, i.e., interspecific, inter- and intravarietal, in the main farm species. The current computational methods facilitate the prediction of the functional consequences of the observed mutations. Subsequently, these predictions can be verified through immunological responsiveness and population-wide association studies. The frequency and haplotype grouping of individual polymorphisms are used to track the origin and selection coefficient as independent indicators of functional changes. The Toll-like receptor variants associated with mastitis and mycobacterial infection have been identified in cattle, consequently, the targeting of these proteins in breeding could contribute to disease control. The range of infections affected by TLR polymorphisms suggests that the improvement of innate resistance is feasible in more species. Thus, the traditional breeds and wild populations should be regarded as the resources of genetic variability accessible for these purposes. (C) 2013 Elsevier B.V. All rights reserved.
dcterms:title
Functional polymorphisms in Toll-like receptor genes for innate immunity in farm animals Functional polymorphisms in Toll-like receptor genes for innate immunity in farm animals
skos:prefLabel
Functional polymorphisms in Toll-like receptor genes for innate immunity in farm animals Functional polymorphisms in Toll-like receptor genes for innate immunity in farm animals
skos:notation
RIV/00027014:_____/14:#0002029!RIV15-MZE-00027014
n4:aktivita
n19:Z
n4:aktivity
Z(MZE0002701404)
n4:cisloPeriodika
1-2
n4:dodaniDat
n10:2015
n4:domaciTvurceVysledku
n18:5906636
n4:druhVysledku
n11:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
17664
n4:idVysledku
RIV/00027014:_____/14:#0002029
n4:jazykVysledku
n8:eng
n4:klicovaSlova
Innate immunity, Toll-like receptors, DNA polymorphism, Health traits
n4:klicoveSlovo
n9:Toll-like%20receptors n9:Innate%20immunity n9:DNA%20polymorphism n9:Health%20traits
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[6F90A67A624D]
n4:nazevZdroje
Veterinary Immunology and Immunopathology 
n4:obor
n6:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
1
n4:rokUplatneniVysledku
n10:2014
n4:svazekPeriodika
157
n4:tvurceVysledku
Novák, Karel
n4:wos
000329952600001
n4:zamer
n14:MZE0002701404
s:issn
0165-2427
s:numberOfPages
11
n17:doi
10.1016/j.vetimm.2013.10.016