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Statements

Subject Item
n2:RIV%2F00027014%3A_____%2F14%3A%230002011%21RIV15-MZE-00027014
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://www.vuzv.cz/sites/File/_privat/14056.pdf
dcterms:description
Hydrophobically modified celluloses were prepared by the esterification of monocarboxycellulose (MCC) and carboxymethylcellulose (CMC) with methanol, followed by the amino-de-alkoxylation of the methyl esters with n-octadecylamine. These cellulose derivatives were fed at 30 and 60 g/kg for 4 weeks to female rats. The diets were supplemented with palm fat (60 or 50 g/kg) and cholesterol (0 or 10 g/kg). There was no significant effect of amidated celluloses on the feed intake or body weight of rats. Both MCC and CMC derivatives significantly decreased the concentrations of cholesterol present in the serum and liver. The supplementation of diets with hydrophobically modified celluloses tended to increase fecal concentrations of cholesterol and coprostanol and significantly increased fecal concentrations of total neutral sterols. In rats fed diets containing cholesterol, the total serum cholesterol correlated negatively with the fecal concentrations of neutral sterols. It can be concluded that MCC-C18 and CMC-C18 are effective cholesterol-lowering agents. Hydrophobically modified celluloses were prepared by the esterification of monocarboxycellulose (MCC) and carboxymethylcellulose (CMC) with methanol, followed by the amino-de-alkoxylation of the methyl esters with n-octadecylamine. These cellulose derivatives were fed at 30 and 60 g/kg for 4 weeks to female rats. The diets were supplemented with palm fat (60 or 50 g/kg) and cholesterol (0 or 10 g/kg). There was no significant effect of amidated celluloses on the feed intake or body weight of rats. Both MCC and CMC derivatives significantly decreased the concentrations of cholesterol present in the serum and liver. The supplementation of diets with hydrophobically modified celluloses tended to increase fecal concentrations of cholesterol and coprostanol and significantly increased fecal concentrations of total neutral sterols. In rats fed diets containing cholesterol, the total serum cholesterol correlated negatively with the fecal concentrations of neutral sterols. It can be concluded that MCC-C18 and CMC-C18 are effective cholesterol-lowering agents.
dcterms:title
Hydrophobically modified celluloses as novel cholesterol-lowering polymers Hydrophobically modified celluloses as novel cholesterol-lowering polymers
skos:prefLabel
Hydrophobically modified celluloses as novel cholesterol-lowering polymers Hydrophobically modified celluloses as novel cholesterol-lowering polymers
skos:notation
RIV/00027014:_____/14:#0002011!RIV15-MZE-00027014
n3:aktivita
n9:Z n9:P
n3:aktivity
P(GAP503/11/2479), Z(MZE0002701404)
n3:cisloPeriodika
3
n3:dodaniDat
n15:2015
n3:domaciTvurceVysledku
n6:7126875 n6:8986185 n6:8763348
n3:druhVysledku
n12:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
20122
n3:idVysledku
RIV/00027014:_____/14:#0002011
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Modified celluloses, Dietary sorbents, Cholesterol, Neutral sterols, Rats
n3:klicoveSlovo
n4:Dietary%20sorbents n4:Rats n4:Modified%20celluloses n4:Cholesterol n4:Neutral%20sterols
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[D727043DF5F1]
n3:nazevZdroje
BioResources
n3:obor
n17:GH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
5
n3:projekt
n16:GAP503%2F11%2F2479
n3:rokUplatneniVysledku
n15:2014
n3:svazekPeriodika
9
n3:tvurceVysledku
Marounek, Milan Dušková, Dagmar Tůma, Jan Volek, Zdeněk Synytsya, Andriy
n3:wos
000344184300043
n3:zamer
n5:MZE0002701404
s:issn
1930-2126
s:numberOfPages
8