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Statements

Subject Item
n2:RIV%2F00027014%3A_____%2F11%3A%230001441%21RIV12-MZE-00027014
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.vuzv.cz/sites/File/_privat/11081.pdf
dcterms:description
The aim of the study was to investigate the effect of testosterone (T) and dihydrotestosterone (DHT) applied alone or in combination with antiandrogen (flutamide) on proliferation, progesterone secretion and telomerase activity (TA) of pig granulosa cells (GC) derived from small (1-3 mm; SF-GC) and large (5-7 mm; LF-GC) ovarian follicles. Cells were treated with investigated factors for 48 h. 5 alpha-DHT stimulated (P<0.05-0.01) proliferation of SF and LF granulosa cells. Flutamide applied individually and in a combination with testosterone and DHT stimulated (P<0.05-0.01) proliferation of pig GC from small and large antral follicles. Flutamide had no effect on progesterone synthesis in small as well as in large follicle GC. Antiandrogen applied individually and in a combination with testosterone and DHT enhanced (P<0.05-0.01) telomerase actitvity in SF-and LF-GC. The results of the study suggest the involvement of androgen receptor in telomerase activity regulation in pig GC and a link between telomerase and the proliferation status of GC. The aim of the study was to investigate the effect of testosterone (T) and dihydrotestosterone (DHT) applied alone or in combination with antiandrogen (flutamide) on proliferation, progesterone secretion and telomerase activity (TA) of pig granulosa cells (GC) derived from small (1-3 mm; SF-GC) and large (5-7 mm; LF-GC) ovarian follicles. Cells were treated with investigated factors for 48 h. 5 alpha-DHT stimulated (P<0.05-0.01) proliferation of SF and LF granulosa cells. Flutamide applied individually and in a combination with testosterone and DHT stimulated (P<0.05-0.01) proliferation of pig GC from small and large antral follicles. Flutamide had no effect on progesterone synthesis in small as well as in large follicle GC. Antiandrogen applied individually and in a combination with testosterone and DHT enhanced (P<0.05-0.01) telomerase actitvity in SF-and LF-GC. The results of the study suggest the involvement of androgen receptor in telomerase activity regulation in pig GC and a link between telomerase and the proliferation status of GC.
dcterms:title
Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro
skos:prefLabel
Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro Androgen receptor inhibitor stimulates telomerase activity of pig granulosa cells in vitro
skos:notation
RIV/00027014:_____/11:#0001441!RIV12-MZE-00027014
n13:predkladatel
n18:ico%3A00027014
n3:aktivita
n11:Z
n3:aktivity
Z(MZE0002701401)
n3:cisloPeriodika
4
n3:dodaniDat
n17:2012
n3:domaciTvurceVysledku
n7:9470638 n7:4586395
n3:druhVysledku
n6:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
186251
n3:idVysledku
RIV/00027014:_____/11:#0001441
n3:jazykVysledku
n19:eng
n3:klicovaSlova
androgen, antiandrogen, granulosa cells, pig, telomerase
n3:klicoveSlovo
n12:pig n12:granulosa%20cells n12:telomerase n12:androgen n12:antiandrogen
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[657A078C0F66]
n3:nazevZdroje
Animal Science Papers and Reports
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n17:2011
n3:svazekPeriodika
29
n3:tvurceVysledku
Kott, Tomáš Chronowska, Ewa
n3:wos
000298158900005
n3:zamer
n14:MZE0002701401
s:issn
0860-4037
s:numberOfPages
11