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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F14%3A43914585%21RIV15-MV0-00023752
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00180/abstract
dcterms:description
The involvement of the serotonin system in the pathophysiology of schizophrenia has been elucidated by experiments with hallucinogens. Application of a hallucinogen to humans leads to changes in perception, cognition, emotions, and induction of psychotic-like symptoms that resemble symptoms of schizophrenia. In rodent studies, their acute administration affects sensonmotor gating, locomotor activity, social behavior, and cognition including working memory, the phenotypes are considered as an animal model of schizophrenia. The complexity and singularity of human cognition raises questions about the validity of animal models utilizing agonists of 5-HT2A receptors. The present study thus investigated the effect of psilocin on memory acquisition, reinforced retrieval, and memory consolidation in rats. Psilocin is a main metabolite of psilocybin acting as an agonist at 5-HT2A receptors with a contribution of 5-HT2C and 5-HT1A receptors. First, we tested the effect of psilocin on the acquisition of a Carousel maze, a spatial task requiring navigation using distal cues, attention, and cognitive coordination. Psilocin significantly impaired the acquisition of the Carousel maze at both doses (1 and 4 mg/kg). The higher dose of psilocin blocked the learning processes even in an additional session when the rats received only saline. Next, we examined the effect of psilocin on reinforced retrieval and consolidation in the Morris water maze (MM). The dose of 4 mg/kg disrupted reinforced retrieval in the MWM. However, the application of a lower dose was without any significant effect. Finally, neither the low nor high dose of psilocin injected post-training caused a deficit in memory consolidation in the MWM. Taken together, the psilocin dose dependently impaired the acquisition of the Carousel maze and reinforced retrieval in MWM; however, it had no effect on memory consolidation. The involvement of the serotonin system in the pathophysiology of schizophrenia has been elucidated by experiments with hallucinogens. Application of a hallucinogen to humans leads to changes in perception, cognition, emotions, and induction of psychotic-like symptoms that resemble symptoms of schizophrenia. In rodent studies, their acute administration affects sensonmotor gating, locomotor activity, social behavior, and cognition including working memory, the phenotypes are considered as an animal model of schizophrenia. The complexity and singularity of human cognition raises questions about the validity of animal models utilizing agonists of 5-HT2A receptors. The present study thus investigated the effect of psilocin on memory acquisition, reinforced retrieval, and memory consolidation in rats. Psilocin is a main metabolite of psilocybin acting as an agonist at 5-HT2A receptors with a contribution of 5-HT2C and 5-HT1A receptors. First, we tested the effect of psilocin on the acquisition of a Carousel maze, a spatial task requiring navigation using distal cues, attention, and cognitive coordination. Psilocin significantly impaired the acquisition of the Carousel maze at both doses (1 and 4 mg/kg). The higher dose of psilocin blocked the learning processes even in an additional session when the rats received only saline. Next, we examined the effect of psilocin on reinforced retrieval and consolidation in the Morris water maze (MM). The dose of 4 mg/kg disrupted reinforced retrieval in the MWM. However, the application of a lower dose was without any significant effect. Finally, neither the low nor high dose of psilocin injected post-training caused a deficit in memory consolidation in the MWM. Taken together, the psilocin dose dependently impaired the acquisition of the Carousel maze and reinforced retrieval in MWM; however, it had no effect on memory consolidation.
dcterms:title
The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat
skos:prefLabel
The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat The effect of psilocin on memory acquisition, retrieval, and consolidation in the rat
skos:notation
RIV/00023752:_____/14:43914585!RIV15-MV0-00023752
n3:aktivita
n11:P n11:I
n3:aktivity
I, P(ED2.1.00/03.0078), P(GA14-03627S), P(GA14-20613S), P(GBP304/12/G069), P(VG20122015075), P(VG20122015080)
n3:cisloPeriodika
Article 180
n3:dodaniDat
n15:2015
n3:domaciTvurceVysledku
n18:7303505
n3:druhVysledku
n13:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
13471
n3:idVysledku
RIV/00023752:_____/14:43914585
n3:jazykVysledku
n14:eng
n3:klicovaSlova
memory; learning; hallucinogenic alkaloids; allocentric navigation; Morris water maze; Carousel maze; spatial memory; psilocin
n3:klicoveSlovo
n8:memory n8:Morris%20water%20maze n8:hallucinogenic%20alkaloids n8:psilocin n8:spatial%20memory n8:Carousel%20maze n8:allocentric%20navigation n8:learning
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[E2274CAFA63A]
n3:nazevZdroje
Frontiers in Behavioral Neuroscience
n3:obor
n17:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n4:ED2.1.00%2F03.0078 n4:GBP304%2F12%2FG069 n4:GA14-20613S n4:VG20122015075 n4:VG20122015080 n4:GA14-03627S
n3:rokUplatneniVysledku
n15:2014
n3:svazekPeriodika
8
n3:tvurceVysledku
Rambousek, Lukáš Páleníček, Tomáš Valeš, Karel Stuchlík, Aleš
n3:wos
000335956600001
s:issn
1662-5153
s:numberOfPages
7
n5:doi
10.3389/fnbeh.2014.00180