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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F14%3A43914582%21RIV15-MV0-00023752
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0091305714000719
dcterms:description
We investigated the potential antipsychotic effects of the mGlu2/3 agonist LY379268 on changes in EEG power spectra and coherence in the ketamine model of psychosis. In EEG experiments, adult male Wistar rats were injected with ketamine 30 mg/kg i.p. and LY379268 3 mg/kg i.p. Cortical EEG was recorded from twelve (2 x 6) electrodes placed homolaterally on each hemisphere. To avoid interference with the behavioral hyperactivity of ketamine challenge, the behavioral activity of animals was simultaneously registered at the time of recording. Subsequent power spectral and coherence analyses were assessed in epochs corresponding to behavioral inactivity. Analysis of segments with behavioral activity compared to inactivity was also performed. The effects of LY379268 3 mg/kg i.p. on the deficits in sensorimotor processing and on hyperlocomotion induced by ketamine were evaluated in the test of prepulse inhibition of acoustic startle reaction and in the open field. LY379268 reversed the ketamine-induced hyperlocomotion but had no effect on ketamine-induced PPI deficits. In EEG epochs corresponding to behavioral inactivity ketamine decreased the power in the delta band, induced a power increase in the high frequency bands and globally decreased EEG coherence. Pretreatment with the LY379268 completely reversed the ketamine-induced power increase in high frequency bands and had a partial effect on EEG coherence. LY379268 alone induced a decrease of beta, high beta and low-gamma power, and an increase in coherence in high frequency bands. Additional analysis revealed that behavioral activity increases power as well as coherence in most frequency bands. In conclusion, agonism of mGlu2/3 receptors was effective in reversing most of the changes induced by ketamine, however due to the lack of effectiveness on PPI deficits its potential antipsychotic properties remain disputable. We investigated the potential antipsychotic effects of the mGlu2/3 agonist LY379268 on changes in EEG power spectra and coherence in the ketamine model of psychosis. In EEG experiments, adult male Wistar rats were injected with ketamine 30 mg/kg i.p. and LY379268 3 mg/kg i.p. Cortical EEG was recorded from twelve (2 x 6) electrodes placed homolaterally on each hemisphere. To avoid interference with the behavioral hyperactivity of ketamine challenge, the behavioral activity of animals was simultaneously registered at the time of recording. Subsequent power spectral and coherence analyses were assessed in epochs corresponding to behavioral inactivity. Analysis of segments with behavioral activity compared to inactivity was also performed. The effects of LY379268 3 mg/kg i.p. on the deficits in sensorimotor processing and on hyperlocomotion induced by ketamine were evaluated in the test of prepulse inhibition of acoustic startle reaction and in the open field. LY379268 reversed the ketamine-induced hyperlocomotion but had no effect on ketamine-induced PPI deficits. In EEG epochs corresponding to behavioral inactivity ketamine decreased the power in the delta band, induced a power increase in the high frequency bands and globally decreased EEG coherence. Pretreatment with the LY379268 completely reversed the ketamine-induced power increase in high frequency bands and had a partial effect on EEG coherence. LY379268 alone induced a decrease of beta, high beta and low-gamma power, and an increase in coherence in high frequency bands. Additional analysis revealed that behavioral activity increases power as well as coherence in most frequency bands. In conclusion, agonism of mGlu2/3 receptors was effective in reversing most of the changes induced by ketamine, however due to the lack of effectiveness on PPI deficits its potential antipsychotic properties remain disputable.
dcterms:title
The effect of ((-)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis The effect of ((-)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis
skos:prefLabel
The effect of ((-)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis The effect of ((-)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis
skos:notation
RIV/00023752:_____/14:43914582!RIV15-MV0-00023752
n4:aktivita
n14:S n14:P n14:I
n4:aktivity
I, P(7E12038), P(VG20122015075), P(VG20122015080), S
n4:cisloPeriodika
July
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n8:9619143 n8:6505422 n8:3784355 n8:4549600 n8:3107299 n8:7356501 n8:7303505 n8:6339824
n4:druhVysledku
n9:J
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
13610
n4:idVysledku
RIV/00023752:_____/14:43914582
n4:jazykVysledku
n15:eng
n4:klicovaSlova
functional connectivity; open field; prepulse inhibition; electroencephalography (EEG); mGlu2/3 agonist LY379268; ketamine
n4:klicoveSlovo
n5:electroencephalography%20%28EEG%29 n5:open%20field n5:functional%20connectivity n5:prepulse%20inhibition n5:ketamine n5:mGlu2%2F3%20agonist%20LY379268
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[40582C89FECB]
n4:nazevZdroje
Pharmacology Biochemistry and Behavior
n4:obor
n17:FL
n4:pocetDomacichTvurcuVysledku
8
n4:pocetTvurcuVysledku
9
n4:projekt
n16:VG20122015075 n16:VG20122015080 n16:7E12038
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
122
n4:tvurceVysledku
Krajča, Vladimír Řípová, Daniela Kubešová, Anna Horáček, Jiří Páleníček, Tomáš Fujáková, Michaela Tylš, Filip Brunovský, Martin Gorman, Ingmar
n4:wos
000338597000024
s:issn
0091-3057
s:numberOfPages
10
n19:doi
10.1016/j.pbb.2014.03.001