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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F13%3A43914462%21RIV14-MZ0-00023752
rdf:type
skos:Concept n5:Vysledek
dcterms:description
OBJECTIVES: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of ketamine has not been explored. We examined the relationship between the antidepressant and psychotomimetic effects of a single ketamine infusion in subjects diagnosed with major depressive disorder. METHODS: In a double-blind, cross-over, placebo-controlled, two weeks clinical trial we studied the effects of ketamine (0.54 mg/kg within 30 min) in a group of 27 hospitalized depressive patients. RESULTS: Higher intensity of psychotomimetic symptoms, measured using BPRS, during ketamine administration correlated with alleviation in mood ratings during the following week with maximum on day seven. Ketamine was superior to placebo in all visits (day 1, 4, and 7) assessed by MADRS with effect size (Cohen's d) of 0.62, 0.57, and 0.44 respectively. There was no significant correlation between ketamine and nor-ketamine plasma levels and MADRS score change at any study time point. CONCLUSION: The substantial relationship between ketamine's antidepressant and psychotomimetic effects was found. This relationship could be mediated by the initial steps of ketamine's action, trough NMDA receptors, shared by both ketamine's clinical effects. OBJECTIVES: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of ketamine has not been explored. We examined the relationship between the antidepressant and psychotomimetic effects of a single ketamine infusion in subjects diagnosed with major depressive disorder. METHODS: In a double-blind, cross-over, placebo-controlled, two weeks clinical trial we studied the effects of ketamine (0.54 mg/kg within 30 min) in a group of 27 hospitalized depressive patients. RESULTS: Higher intensity of psychotomimetic symptoms, measured using BPRS, during ketamine administration correlated with alleviation in mood ratings during the following week with maximum on day seven. Ketamine was superior to placebo in all visits (day 1, 4, and 7) assessed by MADRS with effect size (Cohen's d) of 0.62, 0.57, and 0.44 respectively. There was no significant correlation between ketamine and nor-ketamine plasma levels and MADRS score change at any study time point. CONCLUSION: The substantial relationship between ketamine's antidepressant and psychotomimetic effects was found. This relationship could be mediated by the initial steps of ketamine's action, trough NMDA receptors, shared by both ketamine's clinical effects.
dcterms:title
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression
skos:prefLabel
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression
skos:notation
RIV/00023752:_____/13:43914462!RIV14-MZ0-00023752
n5:predkladatel
n6:ico%3A00023752
n3:aktivita
n12:S n12:P
n3:aktivity
P(NT13403), S
n3:cisloPeriodika
4
n3:dodaniDat
n17:2014
n3:domaciTvurceVysledku
n7:7625952 n7:7891423 n7:7303505 n7:6339824 n7:3683508 n7:4846982
n3:druhVysledku
n8:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
102213
n3:idVysledku
RIV/00023752:_____/13:43914462
n3:jazykVysledku
n11:eng
n3:klicovaSlova
major depressive disorder; NMDA; psychotomimetic; antidepressant; nor-ketamine; ketamine
n3:klicoveSlovo
n4:NMDA n4:psychotomimetic n4:antidepressant n4:major%20depressive%20disorder n4:ketamine n4:nor-ketamine
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[EDE972A29402]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n15:FL
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n16:NT13403
n3:rokUplatneniVysledku
n17:2013
n3:svazekPeriodika
34
n3:tvurceVysledku
Šóš, Peter Klírová, Monika Novák, Tomáš Páleníček, Tomáš Kohútová, Barbora Horáček, Jiří
n3:wos
000330899300007
s:issn
0172-780X
s:numberOfPages
7