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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F13%3A43914231%21RIV14-MZ0-00023752
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://web.natur.cuni.cz/flegr/pdf/schizoonset.pdf
dcterms:description
Objective: Toxoplasmosis is a lifelong parasitic disease that appears to be associated to schizophrenia. However, no distinguishing attributes in Toxoplasma-infected schizophrenia patients have been described as yet. Method: We searched for differences in symptom profile, cognitive performance and treatment response between 194 Toxoplasma-free and 57 (22.7 %) Toxoplasma-infected schizophrenia patients treated in Prague Psychiatric Center between 2000 and 2010. Results: Infected and non-infected patients differed in severity of symptoms (P = 0.032) measured with the Positive and Negative Symptom Scale (PANSS). Infected patients scored higher in positive subscale of PANSS, but not in the general and negative subscales. Infected men scored higher also in Total PANSS score, and negative, reality distortion, disorganisation and cognitive scores. Higher PANSS scores of positive, negative and disorganised psychopathology were associated with the lower titres of anti-Toxoplasma antibodies suggesting that psychopathology deteriorates with duration of parasitic infection. Infected patients remained about 33 days longer in hospital during their last admission than uninfected ones (P = 0.003). Schizophrenia started approximately 1 year earlier in infected men and about 3 years later in infected women, no such difference was observed in uninfected subjects. Conclusion: Latent toxoplasmosis in schizophrenia may lead to more severe positive psychopathology and perhaps less favourable course of schizophrenia. Objective: Toxoplasmosis is a lifelong parasitic disease that appears to be associated to schizophrenia. However, no distinguishing attributes in Toxoplasma-infected schizophrenia patients have been described as yet. Method: We searched for differences in symptom profile, cognitive performance and treatment response between 194 Toxoplasma-free and 57 (22.7 %) Toxoplasma-infected schizophrenia patients treated in Prague Psychiatric Center between 2000 and 2010. Results: Infected and non-infected patients differed in severity of symptoms (P = 0.032) measured with the Positive and Negative Symptom Scale (PANSS). Infected patients scored higher in positive subscale of PANSS, but not in the general and negative subscales. Infected men scored higher also in Total PANSS score, and negative, reality distortion, disorganisation and cognitive scores. Higher PANSS scores of positive, negative and disorganised psychopathology were associated with the lower titres of anti-Toxoplasma antibodies suggesting that psychopathology deteriorates with duration of parasitic infection. Infected patients remained about 33 days longer in hospital during their last admission than uninfected ones (P = 0.003). Schizophrenia started approximately 1 year earlier in infected men and about 3 years later in infected women, no such difference was observed in uninfected subjects. Conclusion: Latent toxoplasmosis in schizophrenia may lead to more severe positive psychopathology and perhaps less favourable course of schizophrenia.
dcterms:title
Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia
skos:prefLabel
Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia Differences in onset of disease and severity of psychopathology between toxoplasmosis-related and toxoplasmosis-unrelated schizophrenia
skos:notation
RIV/00023752:_____/13:43914231!RIV14-MZ0-00023752
n14:predkladatel
n15:ico%3A00023752
n3:aktivita
n7:I n7:P
n3:aktivity
I, P(GA406/04/0097), P(GAP303/11/1398), P(NT13843)
n3:cisloPeriodika
3
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n8:3287254 n8:6229492 n8:3917126 n8:1371576 n8:2479680 n8:4859839 n8:6339824 n8:7844298 n8:7625952
n3:druhVysledku
n11:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
69603
n3:idVysledku
RIV/00023752:_____/13:43914231
n3:jazykVysledku
n10:eng
n3:klicovaSlova
illness onset; infection theory; toxoplasma gondii; psychopathology; schizophrenia
n3:klicoveSlovo
n9:psychopathology n9:infection%20theory n9:schizophrenia n9:illness%20onset n9:toxoplasma%20gondii
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[A37B62E2760C]
n3:nazevZdroje
Acta Psychiatrica Scandinavica
n3:obor
n19:FL
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
12
n3:projekt
n13:GA406%2F04%2F0097 n13:NT13843 n13:GAP303%2F11%2F1398
n3:rokUplatneniVysledku
n6:2013
n3:svazekPeriodika
127
n3:tvurceVysledku
Čermák, Jan Flegr, Jaroslav Rodriguez, Mabel Dragomirecká, Eva Höschl, Cyril Kodym, Petr Libiger, Jan Bankovská Motlová, Lucie Novák, Tomáš Holub, David Preiss, Marek Horáček, Jiří
n3:wos
000314853200008
s:issn
0001-690X
s:numberOfPages
12
n17:doi
10.1111/acps.12031