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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F12%3A43913810%21RIV13-MZ0-00023752
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1750-3639.2011.00525.x
dcterms:description
Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs at tangles in the early and intermediate stages of the maturation. Patological processing of tau protein during the formation and maturation of neurofibrillary tangles includes abnormal phosphorylation, conformational changes and truncation of the C-terminus. Abnormal phosphorylation and misfolding may serve as recognition signals for ubiquitin-targeting and proteosomal processing. Our findings indicate that tau protein in tangles may be dually subjected to both apoptotic and proteosomal processing. However, it appears that ubiquitin targeting of tau protein occurs at tangles in the early and intermediate stages of the maturation.
dcterms:title
Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease
skos:prefLabel
Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer´s disease
skos:notation
RIV/00023752:_____/12:43913810!RIV13-MZ0-00023752
n6:predkladatel
n7:ico%3A00023752
n3:aktivita
n11:Z
n3:aktivity
Z(MZ0PCP2005)
n3:cisloPeriodika
2
n3:dodaniDat
n13:2013
n3:domaciTvurceVysledku
n14:4549600 n14:8482705 Basulto, José Jaime Jarero Garcia-Sierra, Francisco
n3:druhVysledku
n20:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
175587
n3:idVysledku
RIV/00023752:_____/12:43913810
n3:jazykVysledku
n15:eng
n3:klicovaSlova
Alzheimer´s disease; truncation; protein tau
n3:klicoveSlovo
n4:protein%20tau n4:Alzheimer%C2%B4s%20disease n4:truncation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[6BAD779232A0]
n3:nazevZdroje
Brain Pathology
n3:obor
n16:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n13:2012
n3:svazekPeriodika
22
n3:tvurceVysledku
Majer, Emerich Basulto, José Jaime Jarero Garcia-Sierra, Francisco Binder, Lester I. Řípová, Daniela Krištofiková, Zdena
n3:wos
000300834300010
n3:zamer
n19:MZ0PCP2005
s:issn
1015-6305
s:numberOfPages
11
n12:doi
10.1111/j.1750-3639.2011.00525.x