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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F12%3A43913772%21RIV13-MZ0-00023752
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.neures.2012.02.014
dcterms:description
This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. This review focuses on the relationship between psychotropic drugs and adult hippocampal neurogenesis. Adult neurogenesis is important for learning and memory, as well as for depression and anxiety. There is some evidence that chronic treatment with opiates, stimulants and entactogens decreases neurogenesis and consequently impairs cognitive function, as well as inducing depressive-like behaviour in animals during drug withdrawal. On the other hand, NMDA receptor antagonists increase neurogenesis, but negatively affect cognitive function and have an antidepressant-like profile. We suggest that drug-induced changes in neurogenesis have a greater and more concise effect on emotive state reflecting the direction of influencing new cells proliferation than the performance of cognitive tasks. In this review we provide some evidence for this assumption. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
dcterms:title
Impact of psychotropic drugs on adult hippocampal neurogenesis Impact of psychotropic drugs on adult hippocampal neurogenesis
skos:prefLabel
Impact of psychotropic drugs on adult hippocampal neurogenesis Impact of psychotropic drugs on adult hippocampal neurogenesis
skos:notation
RIV/00023752:_____/12:43913772!RIV13-MZ0-00023752
n11:predkladatel
n14:ico%3A00023752
n3:aktivita
n9:I n9:P
n3:aktivity
I, P(NS10378)
n3:cisloPeriodika
2
n3:dodaniDat
n19:2013
n3:domaciTvurceVysledku
n5:3107299 n5:4480813 n5:6339824 n5:4489829 n5:7303505
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
140680
n3:idVysledku
RIV/00023752:_____/12:43913772
n3:jazykVysledku
n20:eng
n3:klicovaSlova
hippocampus; cognitive function; psychotropic drugs; adult neurogenesis
n3:klicoveSlovo
n8:hippocampus n8:adult%20neurogenesis n8:cognitive%20function n8:psychotropic%20drugs
n3:kodStatuVydavatele
IE - Irsko
n3:kontrolniKodProRIV
[AEAF5AF1F69A]
n3:nazevZdroje
Neuroscience Research
n3:obor
n16:FL
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n15:NS10378
n3:rokUplatneniVysledku
n19:2012
n3:svazekPeriodika
73
n3:tvurceVysledku
Bubeníková-Valešová, Věra Páleníček, Tomáš Mertlová, Markéta Kubešová, Anna Horáček, Jiří
n3:wos
000304520200001
s:issn
0168-0102
s:numberOfPages
6
n10:doi
10.1016/j.neures.2012.02.014