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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F12%3A43913770%21RIV13-MZ0-00023752
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1159/000343478
dcterms:description
The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhancing data quality and expanding the palette of tools available to investigate the action of drugs on the central nervous system (CNS), determine the pharmacokinetic and pharmacodynamic properties of novel therapeutics and evaluate the CNS penetration or toxicity of compounds. However, a review of the literature reveals inconsistent operating procedures from one study to another. While this fact does not invalidate results per se, the lack of standardisation constitutes a regrettable shortcoming, especially in the context of drug development programmes. Moreover, this shortcoming hampers reliable comparisons between outcomes of studies from different laboratories and hence also prevents pooling of data which is a requirement for sufficiently powering the validation of novel analytical algorithms and EEG-based biomarkers. The present updated guidelines reflect the consensus of a global panel of EEG experts and are intended to assist investigators using pharmaco-EEG in clinical research, by providing clear and concise recommendations and thereby enabling standardisation of methodology and facilitating comparability of data across laboratories. The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhancing data quality and expanding the palette of tools available to investigate the action of drugs on the central nervous system (CNS), determine the pharmacokinetic and pharmacodynamic properties of novel therapeutics and evaluate the CNS penetration or toxicity of compounds. However, a review of the literature reveals inconsistent operating procedures from one study to another. While this fact does not invalidate results per se, the lack of standardisation constitutes a regrettable shortcoming, especially in the context of drug development programmes. Moreover, this shortcoming hampers reliable comparisons between outcomes of studies from different laboratories and hence also prevents pooling of data which is a requirement for sufficiently powering the validation of novel analytical algorithms and EEG-based biomarkers. The present updated guidelines reflect the consensus of a global panel of EEG experts and are intended to assist investigators using pharmaco-EEG in clinical research, by providing clear and concise recommendations and thereby enabling standardisation of methodology and facilitating comparability of data across laboratories.
dcterms:title
Guidelines for the recording and evaluation of pharmaco-EEG data in man: The international pahrmaco-EEG society (IPEG) Guidelines for the recording and evaluation of pharmaco-EEG data in man: The international pahrmaco-EEG society (IPEG)
skos:prefLabel
Guidelines for the recording and evaluation of pharmaco-EEG data in man: The international pahrmaco-EEG society (IPEG) Guidelines for the recording and evaluation of pharmaco-EEG data in man: The international pahrmaco-EEG society (IPEG)
skos:notation
RIV/00023752:_____/12:43913770!RIV13-MZ0-00023752
n14:predkladatel
n18:ico%3A00023752
n5:aktivita
n9:N n9:V
n5:aktivity
N, V
n5:cisloPeriodika
4
n5:dodaniDat
n15:2013
n5:domaciTvurceVysledku
n10:3784355
n5:druhVysledku
n11:J
n5:duvernostUdaju
n13:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
138536
n5:idVysledku
RIV/00023752:_____/12:43913770
n5:jazykVysledku
n19:eng
n5:klicovaSlova
translatable EEG biomarkers; source localisation; quantitative electroencephalography; pharmacokinetics; pharmaco-EEG; pharmacodynamics; guidelines; electroencephalography; drug development; cordance; central nervous system; biomarkers; y-Activity
n5:klicoveSlovo
n8:y-Activity n8:electroencephalography n8:cordance n8:pharmacodynamics n8:source%20localisation n8:pharmaco-EEG n8:drug%20development n8:biomarkers n8:central%20nervous%20system n8:quantitative%20electroencephalography n8:translatable%20EEG%20biomarkers n8:guidelines n8:pharmacokinetics
n5:kodStatuVydavatele
CH - Švýcarská konfederace
n5:kontrolniKodProRIV
[54E59FA8849A]
n5:nazevZdroje
Neuropsychobiology
n5:obor
n6:FL
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
6
n5:rokUplatneniVysledku
n15:2012
n5:svazekPeriodika
66
n5:tvurceVysledku
Prichep, Leslie Jobert, Marc Drinkenburg, Wilhelmus H. I. M. Brunovský, Martin Wilson, Frederick J. Ruigt, Gé S. F.
n5:wos
000311601100002
s:issn
0302-282X
s:numberOfPages
20
n4:doi
10.1159/000343478