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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F12%3A43913757%21RIV13-MZ0-00023752
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol24_no2/dnb_vol24_no2_188.pdf
dcterms:description
Background: Methamphetamine is a neurotoxic agent. Its chronic abuse may result in cognitive impairment with negative consequences for patients´ treatment and rehabilitation. The aim of the study was to compare Wisconsin Card Sorting Test profiles of Czech subjects dependent on methamphetamine with healthy individuals. Subjects and methods: Forty-three hospitalized Czech Caucasian patients including twenty-seven men at the average age of 25.3+5.2 years dependent on methamphetamine for 6.2+3.3 years were assessed by the Wisconsin Card Sorting Test. We used the same neurocognitive test for the comparison group of healthy controls with the same ethnicity (N=52, men N=28, average age of 38.7+12.1 years). We applied the Chi-Square Test, Two-Sample T Test, Mann-Whitney U Test and Kolmogorov-Smirnov Test to compare methamphetamine dependent patients with healthy volunteers. Results: All recorded Wisconsin Card Sorting Test parameters were significantly different in the group of methamphetamine dependent patients versus healthy volunteers (P=0.04-0.006; Mann-Whitney U Test, Two-Sample T Test). The results showed a higher error rate and a smaller achievement quality in the patients as against healthy subjects. We ascertained a significant cognitive deterioration in the patients as compared to healthy volunteers even if the average patients´ achievements were in the normal range according to the test norms. Conclusions: A cognitive impairment was present in the group of patients as compared to healthy controls. Better understanding of neurocognitive symptoms in methamphetamine dependent subjects should help to generate modern therapeutic approaches, both pharmacological and psychosocial, to prevent or attenuate the long-term negative consequences of methamphetamine use disorders. Background: Methamphetamine is a neurotoxic agent. Its chronic abuse may result in cognitive impairment with negative consequences for patients´ treatment and rehabilitation. The aim of the study was to compare Wisconsin Card Sorting Test profiles of Czech subjects dependent on methamphetamine with healthy individuals. Subjects and methods: Forty-three hospitalized Czech Caucasian patients including twenty-seven men at the average age of 25.3+5.2 years dependent on methamphetamine for 6.2+3.3 years were assessed by the Wisconsin Card Sorting Test. We used the same neurocognitive test for the comparison group of healthy controls with the same ethnicity (N=52, men N=28, average age of 38.7+12.1 years). We applied the Chi-Square Test, Two-Sample T Test, Mann-Whitney U Test and Kolmogorov-Smirnov Test to compare methamphetamine dependent patients with healthy volunteers. Results: All recorded Wisconsin Card Sorting Test parameters were significantly different in the group of methamphetamine dependent patients versus healthy volunteers (P=0.04-0.006; Mann-Whitney U Test, Two-Sample T Test). The results showed a higher error rate and a smaller achievement quality in the patients as against healthy subjects. We ascertained a significant cognitive deterioration in the patients as compared to healthy volunteers even if the average patients´ achievements were in the normal range according to the test norms. Conclusions: A cognitive impairment was present in the group of patients as compared to healthy controls. Better understanding of neurocognitive symptoms in methamphetamine dependent subjects should help to generate modern therapeutic approaches, both pharmacological and psychosocial, to prevent or attenuate the long-term negative consequences of methamphetamine use disorders.
dcterms:title
Comparison of Wisconsin Card Sorting Test results between czech subjects dependent on methamphetamine versus healthy volunteers Comparison of Wisconsin Card Sorting Test results between czech subjects dependent on methamphetamine versus healthy volunteers
skos:prefLabel
Comparison of Wisconsin Card Sorting Test results between czech subjects dependent on methamphetamine versus healthy volunteers Comparison of Wisconsin Card Sorting Test results between czech subjects dependent on methamphetamine versus healthy volunteers
skos:notation
RIV/00023752:_____/12:43913757!RIV13-MZ0-00023752
n17:predkladatel
n18:ico%3A00023752
n4:aktivita
n5:V n5:I
n4:aktivity
I, V
n4:cisloPeriodika
2
n4:dodaniDat
n7:2013
n4:domaciTvurceVysledku
n6:2029391 n6:4859839
n4:druhVysledku
n15:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
128105
n4:idVysledku
RIV/00023752:_____/12:43913757
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Wisconsin Card Sorting test; cognitive impairment; neurotoxicity; methamphetamine dependence
n4:klicoveSlovo
n9:cognitive%20impairment n9:methamphetamine%20dependence n9:neurotoxicity n9:Wisconsin%20Card%20Sorting%20test
n4:kodStatuVydavatele
HR - Chorvatská republika
n4:kontrolniKodProRIV
[7969B28664D8]
n4:nazevZdroje
Psychiatria Danubina
n4:obor
n12:AN
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n7:2012
n4:svazekPeriodika
24
n4:tvurceVysledku
Čermáková, Radka Preiss, Marek Bažant, Jan Čermáková, Eva Tibenská, Andrea Hosák, Ladislav
n4:wos
000305713500012
s:issn
0353-5053
s:numberOfPages
6