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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F11%3A00001138%21RIV12-MZ0-00023752
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=321803&Ausgabe=255066&ProduktNr=224082&filename=321803.pdf
dcterms:description
Aims: This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements locomotion and sensorimotor gating - and the pharmacokinetics of ketamine and norketamine were also conducted. Methods: Ketamine and norketamine levels in rat sera and brains were analyzed by gas chromatography-mass spectrometry after ketamine 30 mg/kg (i.p.). Ketamine 9 and 30 mg/kg (i.p.) were used in the behavioral and EEG experiments. Locomotor effects in an open field test and deficits in prepulse inhibition of acoustic startle reaction (PPI ASR) were evaluated in the behavioral experiments. EEG signals were simultaneously recorded from 12 implanted active electrodes; subsequently, an EEG power spectral and coherence analysis was performed. Results: Ketamine had a rapid penetration into the brain; the peak concentrations of the drug were reached within 15 min after administration. Ketamine induced marked hyperlocomotion and deficits in the PPI ASR. EEG spectral analysis mainly showed increases in EEG power as well as coherence. These were most robust at 10-15 min after the administration and influenced all parts of the spectrum with ketamine 30 mg/kg. Conclusions: Ketamine at behaviorally active doses induces a robust increase in EEG power spectra and coherence. The maximum levels of change correlated with the kinetics of ketamine. Aims: This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements locomotion and sensorimotor gating - and the pharmacokinetics of ketamine and norketamine were also conducted. Methods: Ketamine and norketamine levels in rat sera and brains were analyzed by gas chromatography-mass spectrometry after ketamine 30 mg/kg (i.p.). Ketamine 9 and 30 mg/kg (i.p.) were used in the behavioral and EEG experiments. Locomotor effects in an open field test and deficits in prepulse inhibition of acoustic startle reaction (PPI ASR) were evaluated in the behavioral experiments. EEG signals were simultaneously recorded from 12 implanted active electrodes; subsequently, an EEG power spectral and coherence analysis was performed. Results: Ketamine had a rapid penetration into the brain; the peak concentrations of the drug were reached within 15 min after administration. Ketamine induced marked hyperlocomotion and deficits in the PPI ASR. EEG spectral analysis mainly showed increases in EEG power as well as coherence. These were most robust at 10-15 min after the administration and influenced all parts of the spectrum with ketamine 30 mg/kg. Conclusions: Ketamine at behaviorally active doses induces a robust increase in EEG power spectra and coherence. The maximum levels of change correlated with the kinetics of ketamine.
dcterms:title
Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics
skos:prefLabel
Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics
skos:notation
RIV/00023752:_____/11:00001138!RIV12-MZ0-00023752
n17:predkladatel
n19:ico%3A00023752
n3:aktivita
n12:I n12:S n12:P n12:Z
n3:aktivity
I, P(1M0517), P(NS10374), P(NS10375), P(NS10379), S, Z(MSM0021620816), Z(MZ0PCP2005)
n3:cisloPeriodika
4
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n4:7303505 n4:6339824 n4:7356501 n4:6505422 n4:4489829 n4:4846982 n4:1371576 n4:3683508 n4:3784355 n4:9619143
n3:druhVysledku
n8:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
197060
n3:idVysledku
RIV/00023752:_____/11:00001138
n3:jazykVysledku
n16:eng
n3:klicovaSlova
ketamine; sensorimotor gating; prepulse inhibition; open field; locomotion; electroencephalography, coherence; electroencephalography, power spectra; schizophrenia; functional connectivity
n3:klicoveSlovo
n9:electroencephalography n9:ketamine n9:open%20field n9:power%20spectra n9:locomotion n9:functional%20connectivity n9:prepulse%20inhibition n9:sensorimotor%20gating n9:schizophrenia n9:coherence
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[6B817C7130AD]
n3:nazevZdroje
Neuropsychobiology
n3:obor
n7:FL
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
12
n3:projekt
n6:NS10375 n6:NS10374 n6:1M0517 n6:NS10379
n3:rokUplatneniVysledku
n10:2011
n3:svazekPeriodika
63
n3:tvurceVysledku
Šóš, Peter Fujáková, Michaela Horáček, Jiří Gorman, Ingmar Balíková, Marie Brunovský, Martin Höschl, Cyril Páleníček, Tomáš Krajča, Vladimír Tylš, Filip Bubeníková-Valešová, Věra Tišlerová, Barbora
n3:wos
000290960900002
n3:zamer
n18:MSM0021620816 n18:MZ0PCP2005
s:issn
0302-282X
s:numberOfPages
17
n15:doi
10.1159/000321803