This HTML5 document contains 48 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n9http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n6http://linked.opendata.cz/resource/domain/vavai/projekt/
n10http://linked.opendata.cz/resource/domain/vavai/subjekt/
n11http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023752%3A_____%2F11%3A00001131%21RIV12-MZ0-00023752/
n3http://linked.opendata.cz/ontology/domain/vavai/
shttp://schema.org/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/
rdfshttp://www.w3.org/2000/01/rdf-schema#
skoshttp://www.w3.org/2004/02/skos/core#
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n12http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n19http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n15http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F11%3A00001131%21RIV12-MZ0-00023752
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://node.nel.edu/?node_id=11502
dcterms:description
OBJECTIVE: The regulator of G-protein signaling (RGS) molecules represent a class of proteins that modulate the signaling activity of G-protein coupled receptors. Regulator of G-protein signaling 4 (RGS4) is of particular interest in schizophrenia due to reported downregulation of RGS4 transcripts in schizophrenia as well as a connection between RGS4 and a number of receptors implicated in schizophrenia. The mechanism of RGS4 involvement in the pathophysiology of this illness is not clear. METHODS: To elucidate thise role of RGS4 in pathophysiology of schizophrenia, we silenced RGS4 using siRNAs in human neuroblastoma cell lines and we studied the effects of differential RGS4 expression by microarray. RESULTS AND CONCLUSION: The cell lines with downregulated expression of RGS4 showed 67 genes with changed expression (30 underexpressed and 37 overexpressed). We have detected three subgroups of genes which might be implicated in schizophrenia pathophysiology: histone genes, which suggest epigenetic mechanisms of the disease; genes for transcription factors associated with other genes relevant to schizophrenia pathology (BDNF and DISCI1) and a heterogeneous group containing genes for G-proteins (GPR50 and GPR64) and calcium binding proteins. OBJECTIVE: The regulator of G-protein signaling (RGS) molecules represent a class of proteins that modulate the signaling activity of G-protein coupled receptors. Regulator of G-protein signaling 4 (RGS4) is of particular interest in schizophrenia due to reported downregulation of RGS4 transcripts in schizophrenia as well as a connection between RGS4 and a number of receptors implicated in schizophrenia. The mechanism of RGS4 involvement in the pathophysiology of this illness is not clear. METHODS: To elucidate thise role of RGS4 in pathophysiology of schizophrenia, we silenced RGS4 using siRNAs in human neuroblastoma cell lines and we studied the effects of differential RGS4 expression by microarray. RESULTS AND CONCLUSION: The cell lines with downregulated expression of RGS4 showed 67 genes with changed expression (30 underexpressed and 37 overexpressed). We have detected three subgroups of genes which might be implicated in schizophrenia pathophysiology: histone genes, which suggest epigenetic mechanisms of the disease; genes for transcription factors associated with other genes relevant to schizophrenia pathology (BDNF and DISCI1) and a heterogeneous group containing genes for G-proteins (GPR50 and GPR64) and calcium binding proteins.
dcterms:title
The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia
skos:prefLabel
The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia
skos:notation
RIV/00023752:_____/11:00001131!RIV12-MZ0-00023752
n3:predkladatel
n10:ico%3A00023752
n5:aktivita
n17:P
n5:aktivity
P(1M0517), P(GD309/09/H072), P(NR9324)
n5:cisloPeriodika
3
n5:dodaniDat
n15:2012
n5:domaciTvurceVysledku
n9:3462080 n9:6339824 n9:1371576
n5:druhVysledku
n19:J
n5:duvernostUdaju
n13:S
n5:entitaPredkladatele
n11:predkladatel
n5:idSjednocenehoVysledku
196675
n5:idVysledku
RIV/00023752:_____/11:00001131
n5:jazykVysledku
n16:eng
n5:klicovaSlova
RGS4; genetics of schizophrenia; siRNA; neuroblastoma cell line; microarray
n5:klicoveSlovo
n12:microarray n12:genetics%20of%20schizophrenia n12:siRNA n12:RGS4 n12:neuroblastoma%20cell%20line
n5:kodStatuVydavatele
SE - Švédské království
n5:kontrolniKodProRIV
[24D562B08D9A]
n5:nazevZdroje
Neuroendocrinology Letters
n5:obor
n18:FL
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
4
n5:projekt
n6:NR9324 n6:1M0517 n6:GD309%2F09%2FH072
n5:rokUplatneniVysledku
n15:2011
n5:svazekPeriodika
32
n5:tvurceVysledku
Peková, Soňa Vrajová, Monika Horáček, Jiří Höschl, Cyril
n5:wos
000294089700006
s:issn
0172-780X
s:numberOfPages
7