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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F10%3A00001075%21RIV11-GA0-00023752
rdf:type
skos:Concept n17:Vysledek
dcterms:description
It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescence of samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence a fluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) significant positive co It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescence of samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence a fluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) significant positive co
dcterms:title
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease
skos:prefLabel
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease
skos:notation
RIV/00023752:_____/10:00001075!RIV11-GA0-00023752
n3:aktivita
n14:P
n3:aktivity
P(GA305/09/0457), P(NS10369)
n3:cisloPeriodika
11
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n7:4549600 n7:8482705 n7:9467343 n7:1787977
n3:druhVysledku
n9:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
248071
n3:idVysledku
RIV/00023752:_____/10:00001075
n3:jazykVysledku
n5:eng
n3:klicovaSlova
magnetite nanoparticles; aggregation; Alzheimer disease
n3:klicoveSlovo
n10:Alzheimer%20disease n10:aggregation n10:magnetite%20nanoparticles
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0BC55C82EB9E]
n3:nazevZdroje
Molecular Biosystems
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
8
n3:projekt
n4:GA305%2F09%2F0457 n4:NS10369
n3:rokUplatneniVysledku
n8:2010
n3:svazekPeriodika
6
n3:tvurceVysledku
Čechová, Linda Řípová, Daniela Krištofiková, Zdena Říčný, Jan Antošová, Andrea Klaschka, Jan Gažová, Zuzana Bartoš, Aleš
n3:wos
000282765000013
s:issn
1742-206X
s:numberOfPages
6