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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F10%3A00001054%21RIV11-MZ0-00023752
rdf:type
skos:Concept n13:Vysledek
dcterms:description
The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and metoestral and dioestral phase females (MD females). LSD (5, 50 and 200 μg/kg subcutaneously) attenuated locomotor activity and normal behavioural repertoire, and induced flat body posture, wet dog shakes and disrupted PPI. The most prominent behavioural findings of LSD were for LSD 200 μg/kg which suppressed almost all behavioural activity. LSD had mainly inhibitory locomotor effects in males and MD females, yet in EP female rats LSD increased locomotion during the second half of testing period. The main sex differences were observed in locomotor and exploratory behaviour. Both EP and MD females were The aim of this study was to describe sex differences in the behavioural effects of N,N-diethyllysergamide (LSD) (locomotor activity and other behavioural repertoire in the open field) and its effects on sensorimotor gating in rats (prepulse inhibition (PPI) of the acoustic startle reaction). Three groups of animals were analysed: males, oestral and pro-oestral phase females (EP females), and metoestral and dioestral phase females (MD females). LSD (5, 50 and 200 μg/kg subcutaneously) attenuated locomotor activity and normal behavioural repertoire, and induced flat body posture, wet dog shakes and disrupted PPI. The most prominent behavioural findings of LSD were for LSD 200 μg/kg which suppressed almost all behavioural activity. LSD had mainly inhibitory locomotor effects in males and MD females, yet in EP female rats LSD increased locomotion during the second half of testing period. The main sex differences were observed in locomotor and exploratory behaviour. Both EP and MD females were
dcterms:title
Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition
skos:prefLabel
Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition
skos:notation
RIV/00023752:_____/10:00001054!RIV11-MZ0-00023752
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1M0517), P(NR9324), P(NS10374), P(NS10375), Z(MZ0PCP2005)
n3:cisloPeriodika
4
n3:dodaniDat
n16:2011
n3:domaciTvurceVysledku
n5:7303505 n5:6339824 n5:4489829 n5:7625952
n3:druhVysledku
n11:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
287110
n3:idVysledku
RIV/00023752:_____/10:00001054
n3:jazykVysledku
n14:eng
n3:klicovaSlova
N,N-diethyllysergamide (LSD); locomotion; open field; prepulse inhibition; rats; sex differences
n3:klicoveSlovo
n8:N-diethyllysergamide%20%28LSD%29 n8:N n8:locomotion n8:prepulse%20inhibition n8:sex%20differences n8:rats n8:open%20field
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[AE38B8C3C078]
n3:nazevZdroje
Progress in Neuro-Psychopharmacology & Biological Psychiatry
n3:obor
n17:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n15:NS10374 n15:NS10375 n15:NR9324 n15:1M0517
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
34
n3:tvurceVysledku
Novák, Tomáš Horáček, Jiří Bubeníková-Valešová, Věra Hliňák, Zdeněk Páleníček, Tomáš
n3:wos
000278885700003
n3:zamer
n10:MZ0PCP2005
s:issn
0278-5846
s:numberOfPages
9