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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F10%3A00001049%21RIV11-MZ0-00023752
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Background. Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown. Method. In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers. Results. Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion. Conclusions. Our data indicate that Background. Theta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown. Method. In a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers. Results. Ketamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion. Conclusions. Our data indicate that
dcterms:title
Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect
skos:prefLabel
Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect
skos:notation
RIV/00023752:_____/10:00001049!RIV11-MZ0-00023752
n3:aktivita
n14:I n14:P n14:Z
n3:aktivity
I, P(1M0517), P(NR8792), Z(MSM0021620816)
n3:cisloPeriodika
9
n3:dodaniDat
n16:2011
n3:domaciTvurceVysledku
n7:1371576 n7:1321072 n7:1965247 n7:4489829 n7:8377146 n7:3784355 n7:7625952 n7:7303505 n7:6339824 n7:3683508
n3:druhVysledku
n12:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
290914
n3:idVysledku
RIV/00023752:_____/10:00001049
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Depression; healthy volunteers; ketamine; QEEG; theta cordance
n3:klicoveSlovo
n4:ketamine n4:Depression n4:theta%20cordance n4:healthy%20volunteers n4:QEEG
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CE7A366DE1AD]
n3:nazevZdroje
Psychological Medicine
n3:obor
n18:FL
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
11
n3:projekt
n8:1M0517 n8:NR8792
n3:rokUplatneniVysledku
n16:2010
n3:svazekPeriodika
40
n3:tvurceVysledku
Balíková, M. Brunovský, Martin Bubeníková-Valešová, Věra Kopřivová, Jana Španiel, Filip Mohr, Pavel Novák, Tomáš Horáček, Jiří Páleníček, Tomáš Tišlerová, Barbora Höschl, Cyril
n3:wos
000281408500004
n3:zamer
n13:MSM0021620816
s:issn
0033-2917
s:numberOfPages
9