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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F10%3A00001045%21RIV11-MZ0-00023752
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Numerous studies have observed that offspring of bipolar parents manifest a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology. METHODS: Offspring from well-characterized families with one bipolar parent (high risk) or two well parents (controls) were assessed annually or at anytime symptoms developed using KSADS-PL interviews for up to 15 years. DSM-IV diagnoses were made on blind consensus review using all available clinical material. We compared the age-adjusted risks of lifetime psychopathology between high risk and control subjects and assessed the conditional probability of developing a mood disorder given a history of non-mood disorders. In subjects meeting full DSM-IV criteria for bipolar disorder, we assessed the sequence of psychopathology against a clinical staging model. RESULTS: High risk offspring manifest higher rates of Numerous studies have observed that offspring of bipolar parents manifest a broad spectrum of psychiatric disorders. We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology. METHODS: Offspring from well-characterized families with one bipolar parent (high risk) or two well parents (controls) were assessed annually or at anytime symptoms developed using KSADS-PL interviews for up to 15 years. DSM-IV diagnoses were made on blind consensus review using all available clinical material. We compared the age-adjusted risks of lifetime psychopathology between high risk and control subjects and assessed the conditional probability of developing a mood disorder given a history of non-mood disorders. In subjects meeting full DSM-IV criteria for bipolar disorder, we assessed the sequence of psychopathology against a clinical staging model. RESULTS: High risk offspring manifest higher rates of
dcterms:title
Early stages in the development of bipolar disorder Early stages in the development of bipolar disorder
skos:prefLabel
Early stages in the development of bipolar disorder Early stages in the development of bipolar disorder
skos:notation
RIV/00023752:_____/10:00001045!RIV11-MZ0-00023752
n3:aktivita
n12:V
n3:aktivity
V
n3:cisloPeriodika
1-2
n3:dodaniDat
n7:2011
n3:domaciTvurceVysledku
n15:2224151
n3:druhVysledku
n5:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
255639
n3:idVysledku
RIV/00023752:_____/10:00001045
n3:jazykVysledku
n14:eng
n3:klicovaSlova
bipolar disorders; staging
n3:klicoveSlovo
n13:bipolar%20disorders n13:staging
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[A323195E98A5]
n3:nazevZdroje
Journal of Affective Disorders
n3:obor
n9:FL
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n7:2010
n3:svazekPeriodika
121
n3:tvurceVysledku
Duffy, Anne Hájek, Tomáš Grof, Paul Sherry, Simon B. Alda, M.
n3:wos
000274360200017
s:issn
0165-0327
s:numberOfPages
9